ArticlePlant molecular biology2010
The E2FD/DEL2 factor is a component of a regulatory network controlling cell proliferation and development in Arabidopsis.
Article in Plant molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Atypical E2F transcription factors couple Polycomb Repressive Complex 2 to endosperm cell division and differentiation.Nature plants · 2026Article
- A spatiotemporal atlas of giant-cell formation during Meloidogyne incognita infection in tomato roots.Molecular horticulture · 2026Article
- BvHP4b gene in red beet promotes tuber enlargement and enhances resistance to Pst DC3000.BMC genomics · 2025Article
- The first intron and promoter of Arabidopsis DIACYLGLYCEROL ACYLTRANSFERASE 1 exert synergistic effects on pollen and embryo lipid accumulation.The New phytologist · 2025Article
- Computational Reconstruction of the Transcription Factor Regulatory Network Induced by Auxin inPlants (Basel, Switzerland) · 2024Article
- Sugar signals pedal the cell cycle!Frontiers in plant science · 2024Review
- Transcriptome-based network analysis of cell cycle-related genes in response to blue and red light in maize.AoB PLANTS · 2023Article
- Ectopic Expression of PoplarFrontiers in plant science · 2022Article
- Biological role and mechanism of chromatin readers in plants.Current opinion in plant biology · 2021Review
- Article
- Molecular Analysis of the E2F/DP Gene Family ofFrontiers in plant science · 2021Article
- The differential expression patterns of paralogs in response to stresses indicate expression and sequence divergences.BMC plant biology · 2020Article
- AGC protein kinase AGC1-4 mediates seed size in Arabidopsis.Plant cell reports · 2020Article
- E2FA and E2FB transcription factors coordinate cell proliferation with seed maturation.Development (Cambridge, England) · 2019Article
- Co-expression and Transcriptome Analysis ofFrontiers in plant science · 2018Article
- Enhancing gene regulatory network inference through data integration with markov random fields.Scientific reports · 2017Article
- Distinctive features and differential regulation of the DRTS genes of Arabidopsis thaliana.PloS one · 2017Article
- The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte.The Plant cell · 2014Article
- The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells.Cell death & disease · 2012Article
- Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.The EMBO journal · 2012Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An emerging view of plant cell cycle regulators, including the E2F transcription factors, implicates them in the integration of cell proliferation and development. Arabidopsis encodes six E2F proteins that can act as activators or repressors of E2F-responsive genes. E2FA, E2FB and E2FC interact with the retinoblastoma-like RBR protein and bind to DNA together with their DP partners. In contrast, E2FD, E2FE and E2FF (also known as DEL2, DEL1 and DEL3) are atypical E2Fs that possess duplicated DNA binding regions, lack trans-activating and RBR-binding domains and are believed to act as transcriptional inhibitors/repressors. E2FE/DEL1 has been shown to inhibit the endocycle and E2FF/DEL3 appears to control cell expansion but the role of E2FD/DEL2 has not been reported so far. In this study, we investigated the expression of E2FD/DEL2 and analysed the accumulation of its product. These studies revealed that E2FD/DEL2 accumulation is subject to negative post-translational regulation mediated by the plant hormone auxin. Moreover, the analysis of mutant and transgenic plants characterized by altered expression of E2FD/DEL2 has revealed that this atypical E2F can affect plant growth by promoting cell proliferation and repressing cell elongation. Overexpression of E2FD/DEL2 increased the expression of E2FA, E2FB and E2FE/DEL1 whereas its inactivation led to the up-regulation of genes encoding repressors of cell division. These results suggest that E2FD/DEL2 is part of a regulatory network that controls the balance between cell proliferation and development in Arabidopsis.
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