ArticleJournal of industrial microbiology & biotechnology2010
Acid protease production by solid-state fermentation using Aspergillus oryzae MTCC 5341: optimization of process parameters.
Article in Journal of industrial microbiology & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Comparative RSM and ANN modeling for sustainable production and purification of fungal protease using agro-industrial residues under solid-state fermentation and its industrial applications.Archives of microbiology · 2026Article
- Valorization of Stale Bread and Sunflower Spent Oil via Solid State Fermentation Using Food-Grade Filamentous Fungi.Biotech (Basel (Switzerland)) · 2026Article
- Hybrid modeling for industrial fermentation processes with an "Intra-Batch Experimental Design".Journal of industrial microbiology & biotechnology · 2026Article
- Isolation, identification and optimization of biomass production of native Spirulina species from South of the Caspian Sea.MethodsX · 2025Article
- Unveiling the psychrozyme potential of micro-fungi inhabiting the high altitude passes of the trans-Himalayas.Biotechnology letters · 2025Article
- Process optimization and extraction of alkaline protease from halotolerant Streptomyces sp. VITGS3 and its use as a contact lens cleaner.Journal, genetic engineering & biotechnology · 2025Article
- Response surface optimization of cellulase production by3 Biotech · 2024Article
- Molecular identification of Brazilian Fusarium strains: sources of proteases with milk-clotting properties.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Solid-State Fermentation ofJournal of agricultural and food chemistry · 2023Article
- Enhanced production of alkane hydroxylase from Penicillium chrysogenum SNP5 (MTCC13144) through feed-forward neural network and genetic algorithm.AMB Express · 2022Article
- Enzymatic Bioprospecting of Fungi Isolated from a Tropical Rainforest in Mexico.Journal of fungi (Basel, Switzerland) · 2021Article
- A Comprehensive Insight into Fungal Enzymes: Structure, Classification, and Their Role in Mankind's Challenges.Journal of fungi (Basel, Switzerland) · 2021Review
- Production, Optimization, and Characterization of an Acid Protease from a Filamentous Fungus by Solid-State Fermentation.International journal of microbiology · 2021Article
- Optimization of media composition and growth conditions for production of milk-clotting protease (MCP) from Aspergillus oryzae DRDFS13 under solid-state fermentation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Metabolic Profiling-Based Evaluation of the Fermentative Behavior ofFoods (Basel, Switzerland) · 2020Article
- Enhanced butanol production by optimization of medium parameters usingSaudi journal of biological sciences · 2018Article
- Optimization of Culture Conditions for Enhanced Growth, Lipid and Docosahexaenoic Acid (DHA) Production of Aurantiochytrium SW1 by Response Surface Methodology.Scientific reports · 2018Article
- Statistical optimisation of xylanase production by estuarineJournal, genetic engineering & biotechnology · 2017Article
- High Milk-Clotting Activity Expressed by the Newly Isolated Paenibacillus spp. Strain BD3526.Molecules (Basel, Switzerland) · 2016Article
- A biotechnology perspective of fungal proteases.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2015Review
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3 authors.
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Abstract
Aspergillus oryzae MTCC 5341, when grown on wheat bran as substrate, produces several extracellular acid proteases. Production of the major acid protease (constituting 34% of the total) by solid-state fermentation is optimized. Optimum operating conditions obtained are determined as pH 5, temperature of incubation of 30 degrees C, defatted soy flour addition of 4%, and fermentation time of 120 h, resulting in acid protease production of 8.64 x 10(5) U/g bran. Response-surface methodology is used to generate a predictive model of the combined effects of independent variables such as, pH, temperature, defatted soy flour addition, and fermentation time. The statistical design indicates that all four independent variables have significant effects on acid protease production. Optimum factor levels are pH 5.4, incubation temperature of 31 degrees C, 4.4% defatted soy flour addition, and fermentation time of 123 h to yield a maximum activity of 8.93 x 10(5) U/g bran. Evaluation experiments, carried out to verify the predictions, reveal that A. oryzae produces 8.47 x 10(5) U/g bran, which corresponds to 94.8% of the predicted value. This is the highest acid protease activity reported so far, wherein the fungus produces four times higher activity than previously reported [J Bacteriol 130(1): 48-56, 1977].
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