ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Urinary cadmium, osteopenia, and osteoporosis in the US population.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Urine Cadmium as a Risk Factor for Osteoporosis and Osteopenia: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Associations of multiple toxic metal exposures with metabolic dysfunction-associated fatty liver disease: NHANES 2011-2018.Frontiers in nutrition · 2023Article
- Long-Term Sex-Specific Effects of Cadmium Exposure on Osteoporosis and Bone Density: A 10-Year Community-Based Cohort Study.Journal of clinical medicine · 2022Article
- Proximity to major roads and the incidence of osteoporotic fractures in elderly women: The BONE study in Beijing.Frontiers in public health · 2022Article
- Association between blood cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women.Archives of osteoporosis · 2021Article
- Cadmium exposure negatively affects the microarchitecture of trabecular bone and decreases the density of a subset of sympathetic nerve fibers innervating the developing rat femur.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Additional Burden of Diseases Associated with Cadmium Exposure: A Case Study of Cadmium Contaminated Rice Fields in Mae Sot District, Tak Province, Thailand.International journal of environmental research and public health · 2015Article
- Non-renal effects and the risk assessment of environmental cadmium exposure.Environmental health perspectives · 2014Review
- Environmental cadmium exposure and osteoporosis: a review.International journal of public health · 2013Review
- Low-affinity cation transporter (OsLCT1) regulates cadmium transport into rice grains.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryThe association between cadmium and osteoporosis in a multiethnic population is unclear. We found that urinary cadmium is consistently associated with osteopenia and osteoporosis in the Third National Health and Nutrition Examination Survey, regardless of age, sex, race, and smoking status. Cadmium exposure may be an independent risk factor for osteoporosis.
introductionOur purpose was to test whether cadmium exposure is associated with a higher prevalence of osteopenia and osteoporosis in the general US population and selected subgroups.
methodsWe used multinomial logistic regression to analyze data on 10,978 subjects (aged 30-90) from the Third National Health and Nutrition Examination Survey. We studied the association of urinary cadmium levels (adjusted for urinary creatinine) and the prevalence of osteopenia and osteoporosis as defined by the World Health Organization.
resultsAfter adjustment for age, sex, ethnicity, body mass index, calcium intake, and physical inactivity, odds ratios (ORs) for osteopenia and osteoporosis increased dose dependently with two urinary cadmium levels (in micrograms of urinary cadmium per grams of urinary creatinine: level I, 1.00-1.99 mcg/g; level II, > or =2.00 mcg/g). Osteopenia results were as follows: level I OR, 1.49 (95% confidence interval [CI], 1.24-1.80); level II OR, 2.05 (95% CI, 1.52-2.78). Osteoporosis results were as follows: level I OR, 1.78 (95% CI, 1.26-2.52); level II OR, 3.80 (95% CI, 2.36-6.14). The association was consistent in all age, sex, race, and smoking status subgroups.
conclusionsCadmium exposure may be a potential risk factor for osteopenia and osteoporosis in the general US population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.