ArticleCardiovascular drugs and therapy2009
Resveratrol: a multifunctional compound improving endothelial function. Editorial to: "Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats" by S. Soylemez et al.
Article in Cardiovascular drugs and therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial.European journal of nutrition · 2025Trial
- Simulated microgravity induces a NOX-sensitive oxidative response that is attenuated by resveratrol in human endothelial cells.Scientific reports · 2026Article
- Navigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks.International journal of molecular sciences · 2025Review
- Resveratrol as a cardioprotective adjuvant for 5-fluorouracil in the treatment of gastric cancer cells.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Acute resveratrol exposure does not impact hemodynamics of the fetal sheep.Physiological reports · 2023Article
- Evaluating the inhibitory effect of resveratrol on the multiplication of severalFrontiers in pharmacology · 2023Article
- Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability.Molecules (Basel, Switzerland) · 2021Review
- Resveratrol Protects Optic Nerve Head Astrocytes from Oxidative Stress-Induced Cell Death by Preventing Caspase-3 Activation, Tau Dephosphorylation at SerCellular and molecular neurobiology · 2020Article
- Aging women and their endothelium: probing the relative role of estrogen on vasodilator function.American journal of physiology. Heart and circulatory physiology · 2019Review
- Resveratrol protects against oxidized low‑density lipoprotein‑induced human umbilical vein endothelial cell apoptosis via inhibition of mitochondrial‑derived oxidative stress.Molecular medicine reports · 2017Article
- Chronic in vivo or acute in vitro resveratrol attenuates endothelium-dependent cyclooxygenase-mediated contractile signaling in hypertensive rat carotid artery.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries.Journal of exercise nutrition & biochemistry · 2016Article
- Resveratrol Enhances Autophagic Flux and Promotes Ox-LDL Degradation in HUVECs via Upregulation of SIRT1.Oxidative medicine and cellular longevity · 2016Article
- Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity.Journal of cellular and molecular medicine · 2015Review
- Sustained resveratrol infusion increases natriuresis independent of renal vasodilation.Physiological reports · 2014Article
- Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity.Free radical biology & medicine · 2014Article
- Resveratrol: why is it a promising therapy for chronic kidney disease patients?Oxidative medicine and cellular longevity · 2013Review
- Reactive oxygen and nitrogen species in pathogenesis of vascular complications of diabetes.Diabetes & metabolism journal · 2012Article
- Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling.British journal of pharmacology · 2011Review
- Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation.PloS one · 2011Article
Corrections and comments
- Comment on
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The red wine polyphenol resveratrol boosts endothelium-dependent and -independent vasorelaxations. The improvement of endothelial function by resveratrol is largely attributable to nitric oxide (NO) derived from endothelial NO synthase (eNOS). By stimulating eNOS expression, eNOS phosphorylation and eNOS deacetylation, resveratrol enhances endothelial NO production. By upregulating antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) and suppressing the expression and activity of NADPH oxidases, resveratrol inhibits superoxide-mediated NO inactivation. Some resveratrol effects are mediated by sirtuin 1 (SIRT1) or estrogen receptors, respectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.