ArticlePsychopharmacology2010
Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction.Advances in neurobiology · 2025Review
- Heterozygote Dopamine Transporter Knockout Rats Display Enhanced Cocaine Locomotion in Adolescent Females.International journal of molecular sciences · 2022Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson's disease.NPJ Parkinson's disease · 2021Review
- Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts").Neuroscience and biobehavioral reviews · 2020Review
- Dopamine and addiction: what have we learned from 40 years of research.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice.Psychopharmacology · 2019Article
- Dopamine transporter mutant animals: a translational perspective.Journal of neurogenetics · 2016Review
- Decreased cocaine motor sensitization and self-administration in mice overexpressing cannabinoid CB₂ receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Identification of an intronic cis-acting element in the human dopamine transporter gene.Molecular biology reports · 2012Article
- GSK-3β activity and hyperdopamine-dependent behaviors.Neuroscience and biobehavioral reviews · 2011Review
- Subchronic nandrolone administration reduces cocaine-induced dopamine and 5-hydroxytryptamine outflow in the rat nucleus accumbens.Psychopharmacology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLocomotor sensitization, defined as the progressive and enduring enhancement of the motor stimulant effects elicited by repeated exposure to drugs of abuse, is the consequence of drug-induced cellular neuroadaptations that likely contribute to addictive behavior. Neuroadaptations within the dopaminergic system have been shown to be involved both in the induction phase and in the long-term expression phase of sensitization upon drug readministration after withdrawal. MATERIALS AND
methodsMice lacking the dopamine transporter (DAT-KO) were used to test the effect of constitutive hyperdopaminergia on the durability of behavioral sensitization to both cocaine and ethanol. The effect of the DAT mutation was simultaneously tested on two inbred genetic backgrounds, C57Bl/6 and DBA/2, chosen for their contrasting addiction-related phenotypes, as well as on the hybrid F(1) offspring of a cross between C57Bl/6 and DBA/2 congenic strains. RESULTS AND DISCUSSION: In spite of the absence of the DAT, mutant mice were able to develop long-term expression of sensitization to cocaine. Compared to their wild-type littermates, DAT-KO mice exhibited a markedly increased acute ethanol-evoked locomotor activity and developed stronger behavioral sensitization to ethanol during both induction and long-term expression phases. Interestingly, this increased ethanol-induced sensitization was potentiated by the DBA/2 genetic background.
conclusionThese findings, showing that DAT deletion facilitates sensitization, suggest a cross-sensitization-like effect between genetic- and pharmacological-induced hyperdopaminergia.
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