Evidence map›Paper›PMID 19936982›Full record

ReviewLung2010

Coughing precipitated by Bordetella pertussis infection.

Matthew Hewitt, Brendan J Canning

Abstract readReview
PubMed Publisher
In one paragraph

Review in Lung, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Infectious and Inflammatory Pathways to Cough.Annual review of physiology · 2023
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Virulence Associated Gene 8 ofFrontiers in immunology · 2018
    Article
  7. Review
  8. Pharmacology of Bradykinin-Evoked Coughing in Guinea Pigs.The Journal of pharmacology and experimental therapeutics · 2016
    Article
  9. Review
  10. Article
  11. Article
  12. Serum immunoglobulin G analysis to establish a delayed diagnosis of chronic cough due to Bordetella pertussis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2012
    Article
  13. Modulation of connexin signaling by bacterial pathogens and their toxins.Cellular and molecular life sciences : CMLS · 2011
    Review
  14. Cough: an unmet clinical need.British journal of pharmacology · 2011
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Matthew HewittJohns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
Brendan J Canning
Johns Hopkins Bayview Medical Center · USJohns Hopkins Medicine · US

Funding

Reflexes and Supraesophageal Consequences Reflux DiseaseR01HL083192 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CANNING, BRENDAN J · 2006 to 2010
$1.6M
KININS AS MEDIATORS OF REACTIONSR01HL032272 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CANNING, BRENDAN J · 1985 to 2003
$916k
NHLBI NIH HHS HL083192NHLBI NIH HHS R01 HL032272
6 · The paper itself

Abstract

Infections with the gram-negative bacteria Bordetella pertussis (B. pertussis) have long been recognized as a significant threat to children and are increasingly recognized as a cause of cough in adolescents and adults. Antibiotic therapy, when administered during the virulent stages of the disease, can reduce the duration and severity of symptoms. Unfortunately, there are no effective treatments for the persistent coughing that accompanies and follows the infection. The pathogenesis of B. pertussis infection is briefly reviewed. Also discussed is the evidence supporting the hypothesis that the inflammatory peptide bradykinin may be responsible for the persistent, paroxysmal coughing associated with B. pertussis-initiated illness.

Indexed as

Bordetella InfectionsBordetella pertussisBradykininChildChild, PreschoolCoughHumansVirulenceBradykinin

Identifiers

PMID19936982
OpenAlexW2061629283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.