ArticleBehavior genetics2010
Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains.
Article in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Host genetics maps to behaviour and brain structure in developmental mice.Behavioral and brain functions : BBF · 2025Article
- Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse.Mobile DNA · 2024Article
- Efficient genome editing in wild strains of mice using the i-GONAD method.Scientific reports · 2022Article
- D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.Translational psychiatry · 2022Article
- A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes.Experimental animals · 2021Article
- Possibility of Autonomous Estimation of Shiba Goat's Estrus and Non-Estrus Behavior by Machine Learning Methods.Animals : an open access journal from MDPI · 2020Article
- Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits.Genes, brain, and behavior · 2018Article
- Genetics and Genomics of Social Behavior in a Chicken Model.Genetics · 2018Article
- Genetic Dissection of Trabecular Bone Structure with Mouse Intersubspecific Consomic Strains.G3 (Bethesda, Md.) · 2017Article
- Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice.Genes, brain, and behavior · 2017Article
- Video tracking analysis of behavioral patterns during estrus in goats.The Journal of reproduction and development · 2016Article
- Prefrontal cortical dopamine from an evolutionary perspective.Neuroscience bulletin · 2015Review
- Article
- Segregation of a QTL cluster for home-cage activity using a new mapping method based on regression analysis of congenic mouse strains.Heredity · 2014Article
- Neurogenetics of aggressive behavior: studies in rodents.Current topics in behavioral neurosciences · 2014Review
- Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes.Frontiers in neuroscience · 2014Article
- Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Chromosome substitution strains: gene discovery, functional analysis, and systems studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic studies are indispensable for understanding the mechanisms by which individuals develop differences in social behavior. We report genetic mapping of social interaction behavior using inter-subspecific consomic strains established from MSM/Ms (MSM) and C57BL/6J (B6) mice. Two animals of the same strain and sex, aged 10 weeks, were introduced into a novel open-field for 10 min. Social contact was detected by an automated system when the distance between the centers of the two animals became less than approximately 12 cm. In addition, detailed behavioral observations were made of the males. The wild-derived mouse strain MSM showed significantly longer social contact as compared to B6. Analysis of the consomic panel identified two chromosomes (Chr 6 and Chr 17) with quantitative trait loci (QTL) responsible for lengthened social contact in MSM mice and two chromosomes (Chr 9 and Chr X) with QTL that inhibited social contact. Detailed behavioral analysis of males identified four additional chromosomes associated with social interaction behavior. B6 mice that contained Chr 13 from MSM showed more genital grooming and following than the parental B6 strain, whereas the presence of Chr 8 and Chr 12 from MSM resulted in a reduction of those behaviors. Longer social sniffing was observed in Chr 4 consomic strain than in B6 mice. Although the frequency was low, aggressive behavior was observed in a few pairs from consomic strains for Chrs 4, 13, 15 and 17, as well as from MSM. The social interaction test has been used as a model to measure anxiety, but genetic correlation analysis suggested that social interaction involves different aspects of anxiety than are measured by open-field test.
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