Evidence map›Paper›PMID 19936877›Full record

ArticleInternational journal of hematology2009

The presence of mature granulocytes/monocytes derived from leukemic cells in MLL-associated leukemia.

Shoichi Kobayashi, Masato Obata, Maki Hagihara, Kenji Motohashi, Satomi Ito, Rika Ohshima, Rika Sakai, Atsuo Maruta, Heiwa Kanamori

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Article in International journal of hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shoichi KobayashiDivision of Clinical Laboratory, Kanagawa Cancer Center, Yokohama, Japan.
Masato ObataDivision of Clinical Laboratory, Kanagawa Cancer Center, Yokohama, Japan.
Maki HagiharaDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Kenji MotohashiDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Satomi ItoDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Rika OhshimaDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Rika SakaiDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Atsuo MarutaDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan.
Heiwa KanamoriDepartment of Hematology, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan. kanamori@kcch.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We observed the mature granulocytes/monocytes derived from leukemic cells in patients with acute myeloid leukemia who present mixed lineage leukemia gene (MLL). Morphologic observation and fluorescence in situ hybridization analysis (FISH) for chromosome 11q23 abnormality were studied, and a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) analysis was done to identify the fusion partners with MLL. The bone marrow cells with FISH signals of MLL showed the cell differentiation of the myeloid and/or monocytic lineages in 4 of 6 AML patients. MLL partner genes were AF6, AF9, ELL, and ENL, respectively. There was no correlation between the fusion partner and the appearance of mature cells derived from MLL clones. RT-PCR showed the fusion between MLL exon 9 or 10 and the partner genes in mature granulocytes/monocytes. These findings suggest that subgroup of leukemia cells with MLL rearrangement has the differentiation potential of leukemic cells and mature granulocytes/monocytes derived from MLL clones may be biologically different from normal mature cells.

Indexed as

AdultBone Marrow CellsFemaleGranulocytesHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMonocytesMyeloid-Lymphoid Leukemia ProteinMyeloid-Lymphoid Leukemia Protein

Identifiers

PMID19936877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.