ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Bone loss and the risk of non-vertebral fractures in women and men: the Tromsø study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association between a literature-based genetic risk score and bone mineral density of African American women in Women Health Initiative Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis.Journal of orthopaedic translation · 2025Article
- Association of follicle-stimulating hormone with bone turnover markers and bone mineral density in Chinese women across the menopausal transition.Journal of clinical laboratory analysis · 2023Article
- Anti-Mullerian Hormone as Predictor of Future and Ongoing Bone Loss During the Menopause Transition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women.Frontiers in endocrinology · 2022Article
- Faster Lumbar Spine Bone Loss in Midlife Predicts Subsequent Fracture Independent of Starting Bone Mineral Density.The Journal of clinical endocrinology and metabolism · 2021Article
- Peak trabecular bone microstructure predicts rate of estrogen-deficiency-induced bone loss in rats.Bone · 2021Article
- Estradiol and Follicle-Stimulating Hormone as Predictors of Onset of Menopause Transition-Related Bone Loss in Pre- and Perimenopausal Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis.Journal of orthopaedic surgery and research · 2017Article
- Diagnosis and therapy of osteoporosis in geriatric trauma patients: an update.Innovative surgical sciences · 2016Review
- Value of a coordinated management of osteoporosis via Fracture Liaison Service for the treatment of orthogeriatric patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Article
- Fracture prediction from repeat BMD measurements in clinical practice.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Bone Mineral Density as a Predictor of Subsequent Wrist Fractures: Findings From the Women's Health Initiative Study.The Journal of clinical endocrinology and metabolism · 2015Observational
- [Identification, diagnostics and guideline conform therapy of osteoporosis (DVO) in trauma patients : a treatment algorithm].Der Unfallchirurg · 2015Article
- Low serum concentrations of alpha-tocopherol are associated with increased risk of hip fracture. A NOREPOS study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- A cohort study for the impact of activity-limiting injuries based on the Canadian National Population Health Survey 1994-2006.BMJ open · 2013Article
- Diabetes and change in bone mineral density at the hip, calcaneus, spine, and radius in older women.Frontiers in endocrinology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryWe assessed the association between the rate of forearm bone loss and non-vertebral fracture. Bone loss at the distal forearm predicted fractures, independently of baseline BMD, but not independently of follow-up BMD in women. The BMD level where an individual ends up is the significant predictor of fracture risk.
introductionBone loss may predict fracture risk independently of baseline BMD. The influence of follow-up BMD on this prediction is unknown. The aim of this study was to assess the association between bone loss and fracture risk in both sexes in a prospective population-based study.
methodsWe included 1,208 postmenopausal women (50 to 74 years), and 1,336 men (55 to 74 years) from the Tromsø Study, who had repeated distal and ultra-distal forearm BMD measurements. Non-vertebral fractures were registered from 2001 to 2005.
resultsA total of 100 women and 46 men sustained fractures during the follow-up time. Independent of baseline BMD, the RR associated with distal site bone loss of 1 SD %/year was 1.23 (1.01-1.50) for low-trauma fractures (excluding hand, foot, skull & high-trauma) and 1.32 (1.07-1.62) for osteoporotic fractures (hip, wrist and shoulder). However, bone loss did not predict fracture after adjusting for follow-up BMD. The BMD level where an individual ends up became the significant predictor of fracture risk and not the rate of bone loss. Follow-up BMD at ultra-distal site was associated with low-trauma fractures in both sexes. While ultra-distal site BMD changes were not associated with fracture risk in both sexes.
conclusionBone loss at the distal forearm predicted non-vertebral fractures, independently of baseline BMD, but not independently of follow-up BMD, in women. The BMD level where an individual ends up is the significant predictor of fracture risk and not the rate of bone loss.
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