ReviewVirchows Archiv : an international journal of pathology2010
Soft tissue tumors associated with EWSR1 translocation.
Review in Virchows Archiv : an international journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 154 citations in OpenAlex.
- Establishment of Salivary Gland Tumors Arising in Salivary Gland-Specific EWSR1::ATF1 Transgenic Mice.Head & neck · 2026Article
- Clear cell sarcoma metastasizing to the pancreas.World journal of clinical cases · 2024Article
- Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro.Scientific reports · 2024Article
- Enhancing the Impact of Chemotherapy on Ewing Sarcoma Cells through Combination with Cold Physical Plasma.International journal of molecular sciences · 2023Article
- The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.Scientific reports · 2023Article
- Molecular classification of soft tissue sarcomas for adequate diagnosis: A study on the northeast population of Morocco.Heliyon · 2022Article
- Genomic Landscapes of Epstein-Barr Virus in Pulmonary Lymphoepithelioma-Like Carcinoma.Journal of virology · 2022Article
- EWSR1 rearrangement in papillary thyroid microcarcinoma is related to classic morphology and the presence of small-cell phenotype.Bosnian journal of basic medical sciences · 2022Article
- Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report.Brain tumor pathology · 2021Article
- RNA-binding proteins of COSMIC importance in cancer.The Journal of clinical investigation · 2021Review
- Rare intracranialBMJ case reports · 2021Article
- [New in the current WHO classification (2020) for soft tissue sarcomas].Der Pathologe · 2021Review
- Systems Biology Analysis for Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2021Article
- An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer.International journal of molecular sciences · 2020Review
- Desmoplastic small round cell tumor showing solid proliferation with limited desmoplasia and confusing immunohistochemical findings: an autopsy report.Medical molecular morphology · 2020Article
- The role of molecular pathology in mediastinal sarcomas.Mediastinum (Hong Kong, China) · 2020Review
- Ewing's sarcoma in the spinal canal of T12-L3: A case report and review of the literature.Oncology letters · 2019Article
- Unexpected pulmonary tumour in a young woman.Journal of clinical pathology · 2019Article
- Article
- Limited biopsies of soft tissue tumors: the contemporary role of immunohistochemistry and molecular diagnostics.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ewing sarcoma breakpoint region 1 (EWSR1; also known as EWS) represents one of the most commonly involved genes in sarcoma translocations. In fact, it is involved in a broad variety of mesenchymal lesions which includes Ewing's sarcoma/peripheral neuroectodermal tumor, desmoplastic small round cell tumor,clear cell sarcoma, angiomatoid fibrous histiocytoma, extraskeletal myxoid chondrosarcoma, and a subset of myxoid liposarcoma. The fusion products between EWSR1 and partners usually results in fusion of the N-terminal transcription-activating domain of EWSR1 and the C-terminal DNA-binding domain of the fusion partner, eventually generating novel transcription factors. EWSR1 rearrangement can be visualized by the means of fluorescence in situ hybridization (FISH). As soft tissue sarcomas represent a diagnostically challenging group, FISH analysis is an extremely useful confirmatory diagnostic tool. However, as in most instances a split-apart approach is used, the results of molecular genetics must be evaluated in context with morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.