ArticlePsychopharmacology2010
Tobacco smoke exposure induces nicotine dependence in rats.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 81 citations in OpenAlex.
- Association between nicotine withdrawal and reward responsiveness in humans and rats.JAMA psychiatry · 2014Trial
- Effectiveness of Juniper Essential Oils in Reducing Selected Cigarette Smoke Toxicants, Improving Oxidative Parameters, and Cytotoxicity Against Lung Adenocarcinoma.Biochemistry research international · 2025Article
- Flavokavains A- and B-Free Kava Enhances Resilience against the Adverse Health Effects of Tobacco Smoke in Mice.ACS pharmacology & translational science · 2024Article
- Sex differences in nicotine intake and relapse behavior in nicotine-dependent adult wistar rats.Frontiers in pharmacology · 2024Article
- Fatty Acid-Binding Protein 5 Gene Deletion Enhances Nicotine-Conditioned Place Preference: Illuminating the Putative Gateway Mechanisms.Future pharmacology · 2023Article
- Chronic exposure to cigarette smoke extract increases nicotine withdrawal symptoms in adult and adolescent male rats.Advances in drug and alcohol research · 2023Article
- Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers.Frontiers in psychiatry · 2022Article
- Cumulative disadvantage as a framework for understanding rural tobacco use disparities.Experimental and clinical psychopharmacology · 2021Review
- Rodent models for nicotine withdrawal.Journal of psychopharmacology (Oxford, England) · 2021Review
- Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice.Addiction biology · 2021Article
- Tobacco smoke exposure enhances reward sensitivity in male and female rats.Psychopharmacology · 2021Article
- Chronic exposure to cigarette smoke extract upregulates nicotinic receptor binding in adult and adolescent rats.Neuropharmacology · 2020Article
- Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats.Neuropharmacology · 2020Article
- Exposure to smoke from high- but not low-nicotine cigarettes leads to signs of dependence in male rats and potentiates the effects of nicotine in female rats.Pharmacology, biochemistry, and behavior · 2020Article
- Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats.Drug and alcohol dependence · 2019Article
- Pharmacokinetic and Pharmacodynamic Characterization of Tetrahydrocannabinol-Induced Cannabinoid Dependence After Chronic Passive Cannabis Smoke Exposure in Rats.Cannabis and cannabinoid research · 2019Article
- Enhancing effects of acute exposure to cannabis smoke on working memory performance.Neurobiology of learning and memory · 2019Article
- Effects of nicotine-containing and "nicotine-free" e-cigarette refill liquids on intracranial self-stimulation in rats.Drug and alcohol dependence · 2018Article
- Effect of Prenatal Exposure to Waterpipe Tobacco Smoke on Learning and Memory of Adult Offspring Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Article
- Long-Term Stress and Concomitant Marijuana Smoke Exposure Affect Physiology, Behavior and Adult Hippocampal Neurogenesis.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleTobacco smoke contains nicotine and many other compounds that act in concert on the brain reward system. Therefore, animal models are needed that allow the investigation of chronic exposure to the full spectrum of tobacco smoke constituents.
objectivesThe aim of these studies was to investigate if exposure to tobacco smoke leads to nicotine dependence in rats.
methodsThe intracranial self-stimulation procedure was used to assess the negative affective aspects of nicotine withdrawal. Somatic signs were recorded from a checklist of nicotine abstinence signs. Nicotine self-administration sessions were conducted to investigate if tobacco smoke exposure affects the motivation to self-administer nicotine. Nicotinic receptor autoradiography was used to investigate if exposure to tobacco smoke affects central alpha7 nicotinic acetylcholine receptor (nAChR) and non-alpha7 nAChR levels (primarily alpha4beta2 nAChRs).
resultsThe nAChR antagonist mecamylamine dose-dependently elevated the brain reward thresholds of the rats exposed to tobacco smoke and did not affect the brain reward thresholds of the untreated control rats. Furthermore, mecamylamine induced more somatic withdrawal signs in the smoke-exposed rats than in the control rats. Nicotine self-administration was decreased 1 day after the last tobacco smoke exposure sessions and was returned to control levels 5 days later. Tobacco smoke exposure increased the alpha7 nAChR density in the CA2/3 area and the stratum oriens and increased the non-alpha7 nAChR density in the dentate gyrus.
conclusionTobacco smoke exposure leads to nicotine dependence as indicated by precipitated affective and somatic withdrawal signs and induces an upregulation of nAChRs in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.