Trial reportThe journal of headache and pain2010
Post-infectious new daily persistent headache may respond to intravenous methylprednisolone.
Trial report in The journal of headache and pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports.Frontiers in pain research (Lausanne, Switzerland) · 2024Pooled it
- New daily persistent headache: a systematic review on an enigmatic disorder.The journal of headache and pain · 2019Pooled it
- Article
- Review
- Acute and Preventive Treatment of COVID-19-Related Headache: A Series of 100 Patients.Life (Basel, Switzerland) · 2024Article
- New Daily Persistent Headache (NDPH): Unraveling the Complexities of Diagnosis, Pathophysiology, and Treatment.Current pain and headache reports · 2023Review
- Headache in COVID-19 and Long COVID: to Know Facts for Clinical Practice.Current neurology and neuroscience reports · 2023Review
- Pain Management in the Post-COVID Era-An Update: A Narrative Review.Pain and therapy · 2023Review
- New-onset headache following COVID-19: An Italian multicentre case series.Journal of the neurological sciences · 2023Article
- Long COVID headache.The journal of headache and pain · 2022Review
- The Enigma of New Daily Persistent Headache: What Solutions for Pediatric Age?Current pain and headache reports · 2022Review
- New Daily Persistent Headache-like Presentation Triggered by a Sudden Head Drop in a Patient With Myasthenia Gravis.Neurology. Clinical practice · 2021Article
- Features and Management of New Daily Persistent Headache in Developmental-Age Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine.SAGE open medical case reports · 2019Article
- Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal.The journal of headache and pain · 2017Review
- Update on New Daily Persistent Headache.Current treatment options in neurology · 2016Review
- New daily persistent headache: an update.Current pain and headache reports · 2014Review
- New daily persistent headache and potential new therapeutic agents.Current neurology and neuroscience reports · 2014Review
- New daily persistent headache.Annals of Indian Academy of Neurology · 2012Article
- Refining clinical features and therapeutic options of new daily persistent headache: a retrospective study of 63 patients in India.The journal of headache and pain · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New daily persistent headache (NDPH) is a subtype of chronic daily headache (CDH) that starts acutely and continues as a daily headache from the onset.It is considered as one of the most treatment refractory of all headache syndromes. The pathophysiology is largely unknown. Viral infections, extracranial surgery, and stressful life events are considered as triggers for the onset of NDPH. A few patients may have the onset of their symptoms during an infection. Here we report nine patients with NDPH like headache. All of them had a history suggestive of extracranial infections a few weeks prior to the onset of headache. All patients received intravenous methylprednisolone (IV MPS) for 5 days. Intravenous MPS was followed by Oral steroids for 2-3 weeks in six patients.The relief of headache started between the second and fifth days of infusion in all patients. The steady improvement in headache continued and seven patients experienced almost complete improvement within 2 weeks. Two other patients showed complete improvement between 6 and 8 weeks after initiation of IV MPS therapy. We conclude that NDPH-like headache may occur as a post infectious process following a recent infection. We also speculate on the possible mechanisms of headache in our patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.