ArticleFrontiers in molecular neuroscience2009
Glycine Receptors Caught between Genome and Proteome - Functional Implications of RNA Editing and Splicing.
Article in Frontiers in molecular neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Molecular determinants of cesium- and glycine-dependent glycine receptor activation.Scientific reports · 2025Article
- Pleiotropic neurotransmitters: neurotransmitter-receptor crosstalk regulates excitation-inhibition balance in social brain functions and pathologies.Frontiers in neuroscience · 2025Review
- Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate.International journal of molecular sciences · 2023Article
- Cesium activates the neurotransmitter receptor for glycine.Frontiers in molecular neuroscience · 2023Article
- Glycine encephalopathy.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022Review
- Integration of Metabolomics and Transcriptomicsto Comprehensively Evaluate the Metabolic Effects ofAnimals : an open access journal from MDPI · 2021Article
- Anxiolytic Action of Taurine via Intranasal Administration in Mice.Biomolecules & therapeutics · 2019Article
- The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC-MS Based Metabolomics.Frontiers in pharmacology · 2019Article
- A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA editChemical science · 2018Article
- Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens.The Journal of physiology · 2017Article
- A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.Frontiers in molecular neuroscience · 2017Article
- Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.The Journal of biological chemistry · 2016Article
- Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- RNA Editing-Systemic Relevance and Clue to Disease Mechanisms?Frontiers in molecular neuroscience · 2016Review
- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Gene Expression Switching of Receptor Subunits in Human Brain Development.PLoS computational biology · 2015Article
- Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores.Integrative and comparative biology · 2015Review
- Glycine transporter 1 is a target for the treatment of epilepsy.Neuropharmacology · 2015Article
- Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses.Pharmacological research · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged due to the discovery of posttranscriptional processing. GLR transcripts are edited through enzymatic modification of a single nucleotide leading to amino acid substitution within the neurotransmitter binding domain. RNA editing produces gain-of-function receptors well suited for generation and maintenance of tonic inhibition of neuronal excitability. As neuronal activity deprivation in early stages of development or in epileptic tissue is detrimental to neurons and because RNA editing of GlyR is up-regulated in temporal lobe epilepsy patients with a severe course of disease a pathophysiological role of these receptors emerges. This review contains a state-of-the-art discussion of (patho)physiological implications of GlyR RNA editing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.