ArticlePloS one2009
Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses.Life science alliance · 2025Article
- Kinetics of phagosome maturation is coupled to their intracellular motility.Communications biology · 2022Article
- Targeting the polarization of tumor-associated macrophages and modulating mir-155 expression might be a new approach to treat diffuse large B-cell lymphoma of the elderly.Cancer immunology, immunotherapy : CII · 2019Article
- Enhanced Neutrophil Immune Homeostasis Due to Deletion of PHLPP.Frontiers in immunology · 2019Article
- Innate Immune Recognition: An Issue More Complex Than Expected.Frontiers in cellular and infection microbiology · 2019Review
- Critical Role of Macrophage FcγR Signaling and Reactive Oxygen Species in Alloantibody-Mediated Hepatocyte Rejection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Purified Streptococcus pneumoniae Endopeptidase O (PepO) Enhances Particle Uptake by Macrophages in a Toll-Like Receptor 2- and miR-155-Dependent Manner.Infection and immunity · 2017Article
- Efficacy of Resistance toFrontiers in immunology · 2017Article
- Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis.Journal of the American Heart Association · 2016Article
- Using host-pathogen protein interactions to identify and characterize Francisella tularensis virulence factors.BMC genomics · 2015Article
- Macrophage cell death upon intracellular bacterial infection.Macrophage · 2015Article
- Fcγ receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.The Journal of biological chemistry · 2013Article
- Temporal transcriptional response during infection of type II alveolar epithelial cells with Francisella tularensis live vaccine strain (LVS) supports a general host suppression and bacterial uptake by macropinocytosis.The Journal of biological chemistry · 2013Article
- Subversion of host recognition and defense systems by Francisella spp.Microbiology and molecular biology reviews : MMBR · 2012Review
- MiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis.Frontiers in cellular and infection microbiology · 2012Article
- Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt.Frontiers in microbiology · 2011Article
- Immunity to Francisella.Frontiers in microbiology · 2011Article
- Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis.PloS one · 2010Article
- Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Francisella tularensis infects macrophages and escapes phago-lysosomal fusion to replicate within the host cytosol, resulting in host cell apoptosis. Here we show that the Fas-mediated death pathway is activated in infected cells and correlates with escape of the bacterium from the phagosome and the bacterial burden. Our studies also demonstrate that constitutive activation of Akt, or deletion of SHIP, promotes phago-lysosomal fusion and limits bacterial burden in the host cytosol, and the subsequent induction of Fas expression and cell death. Finally, we show that phagosomal escape/intracellular bacterial burden regulate activation of the transcription factors sp1/sp3, leading to Fas expression and cell death. These data identify for the first time host cell signaling pathways that regulate the phagosomal escape of Francisella, leading to the induction of Fas and subsequent host cell death.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.