ArticleClinics (Sao Paulo, Brazil)2009
Fresh soy oil protects against vascular changes in an estrogen-deficient rat model: an electron microscopy study.
Article in Clinics (Sao Paulo, Brazil), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 25 citations in OpenAlex.
- A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions.Frontiers in cardiovascular medicine · 2026Review
- Article
- Lipidemic effects of common edible oils and risk of atherosclerosis in diabetic Wistar rats.ARYA atherosclerosis · 2017Article
- Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice.Clinics (Sao Paulo, Brazil) · 2011Article
- The effects of heated vegetable oils on blood pressure in rats.Clinics (Sao Paulo, Brazil) · 2011Article
- Abdominal adiposity, insulin and bone quality in young male rats fed a high-fat diet containing soybean or canola oil.Clinics (Sao Paulo, Brazil) · 2011Article
- Expression of TGF-β1 in the blood during fracture repair in an estrogen-deficient rat model.Clinics (Sao Paulo, Brazil) · 2011Article
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4 authors at 1 institution in 1 country.
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Abstract
objectiveTo observe the effects of consuming repeatedly heated soy oil on the aortic tissues of estrogen-deficient rats.
methodsThirty female Sprague Dawley rats (200-250 g) were divided equally into five groups. One group served as the normal control (NC) group. The four treated groups were ovariectomized and were fed as follows: 2% cholesterol diet (OVXC); 2% cholesterol diet + fresh soy oil (FSO); 2% cholesterol diet + once-heated soy oil (1HSO); and 2% cholesterol diet + five-times-heated soy oil (5HSO). After four months, the rats were sacrificed, and the aortic tissues were obtained for histological studies.
resultsAfter four months of feeding, the NC, FSO and 1HSO groups had a lower body weight gain compared to the OVXC and 5HSO groups. The tunica intima/media ratio in the 5HSO group was significantly thicker (p < 0.05) compared to the NC, OVXC and FSO groups. Electron microscopy showed that endothelial cells were normally shaped in the FSO and NC groups but irregular in the 1HSO and 5HSO groups. A greater number of collagen fibers and vacuoles were observed in the 5HSO group compared to the other treatment groups.
conclusionsFresh soy oil offered protection in the estrogen-deficient state, as these rats had similar features to those of the NC group. The damage to the tunica intima and the increase in the ratio of tunica intima/media thickness showed the deleterious effect of consuming repeatedly heated soy oil in castrated female rats.
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