ArticleEpilepsy currents
Epilepsy and the plastic mind.
Article in Epilepsy currents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Gadd45 in Neuronal Development, Function, and Injury.Advances in experimental medicine and biology · 2022Review
- The role of Gadd45b in neurologic and neuropsychiatric disorders: An overview.Frontiers in molecular neuroscience · 2022Review
- N-Methyl d-Aspartate Receptor Expression Patterns in the Human Fetal Cerebral Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- From histology to neurocognition: the influence of tumor grade in glioma of the left temporal lobe on neurocognitive function.Neuro-oncology · 2015Article
- Relationships between tumor grade and neurocognitive functioning in patients with glioma of the left temporal lobe prior to surgical resection.Neuro-oncology · 2015Article
- Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system.The Yale journal of biology and medicine · 2014Review
- Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements.Frontiers in cellular neuroscience · 2013Article
- Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy.Acta neuropathologica · 2012Article
- Rafts, Nanoparticles and Neural Disease.Nanomaterials (Basel, Switzerland) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Seizures are linked to many neuroplastic changes within hippocampal circuits, including alterations in neurogenesis and dendritic growth in the dentate gyrus. How do brief seizures cause the long-term plastic changes in the hippocampus that are associated with recurrent epilepsy? Recent experiments by Ma and colleagues provide insights. They demonstrate an epigenetic mechanism for long-lasting neuroplastic changes that is both activity-dependent and brain region-specific. Focusing on Gadd45b, a DNA excision repair gene, they show it is up-regulated after electroconvulsive seizures or glutamate dependent activation of NMDA receptors. Gadd45b demethylates DNA regulatory elements in promoters of genes encoding fibroblast growth factor 1 and brain-derived neurotrophic factor, increasing the expression of these genes within granule neurons of the dentate gyrus. These changes in growth factor expression promote neurogenesis in the subgranular zone and dendritic growth in the granule cell layer of the dentate gyrus. Further regional and temporal differences in the proliferation of astrocytes and microglia after seizures were demonstrated by two additional studies. Together this work highlights how activity-dependent epigenetic modifications to DNA can alter gene expression with remarkable regional and cell type specificity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.