ArticleMolecular vision2009
Increased neuronal nitric oxide synthase activity in retinal neurons in early diabetic retinopathy.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Retinoprotective effect of agmatine in streptozotocin-induced diabetic rat model: avenues for vascular and neuronal protection : Agmatine in diabetic retinopathy.Journal of physiology and biochemistry · 2021Article
- Effects of high-fat diet and Apoe deficiency on retinal structure and function in mice.Scientific reports · 2020Article
- Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study.Journal of clinical medicine · 2020Article
- Retinal Physiology and Circulation: Effect of Diabetes.Comprehensive Physiology · 2020Review
- Triamcinolone acetonide combined with aminoguanidine inhibits inflammation and oxidative stress, improves vascular endothelial and retinal function and reduces VEGF expression in diabetic retinopathy patients.Experimental and therapeutic medicine · 2020Article
- Altered expression of nNOS/NIDD in the retina of a glaucoma model of DBA/2J mice and the intervention by nNOS inhibition.Journal of molecular neuroscience : MN · 2013Article
- Next-generation sequencing analysis of gene regulation in the rat model of retinopathy of prematurity.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy.Experimental cell research · 2013Article
- Animal models of diabetic retinopathy: summary and comparison.Journal of diabetes research · 2013Review
- Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy.Journal of ocular biology, diseases, and informatics · 2011Article
- Exercise training normalizes impaired NOS-dependent responses of cerebral arterioles in type 1 diabetic rats.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThere are increased levels of nitric oxide (NO) in diabetic retinas. The purpose of this study was to determine the extent that neuronal nitric oxide synthase (nNOS) contributes to the increased levels of retinal NO in early diabetic retinopathy by examining the expression and activity of nNOS in retinal neurons after 5 weeks of diabetes.
methodsChanges in NO levels were measured using NO imaging of retinal neurons in mice with streptozotocin-induced diabetes for five weeks. NO imaging was compared to nNOS localization using immunocytochemistry, and nNOS message and protein levels were measured using quantitative real-time PCR and western blots.
resultsThere was a close anatomic correlation between the localization of the increased NO production and the nNOS immunoreactivity in the retinal plexiform layers of diabetic retinas. There was no change in nNOS message, but nNOS protein was decreased and its subcellular localization was altered. Treatment with insulin or aminoguanidine partially ameliorated the increase in NO in diabetic retinas.
conclusionsThese results suggest that increased nNOS activity is responsible for the majority of increased NO in retinal neurons in early diabetic retinopathy. This supports a role for increased nNOS activity in the early neuronal dysfunction in the diabetic retina.
Indexed as
Identifiers
19936028PMC2776346W2116680504What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.