ArticleBritish journal of cancer2010
Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON).
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 8 of them syntheses that pooled it.
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Who cites it
74 citing papers in PubMed, 8 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Screening for lung cancer: A systematic review of overdiagnosis and its implications.Molecular oncology · 2026Pooled it
- Participant factors associated with psychosocial impacts of lung cancer screening: A systematic review.Cancer medicine · 2024Pooled it
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Psychological Burden Associated With Lung Cancer Screening: A Systematic Review.Clinical lung cancer · 2016Pooled it
- Patient-centered outcomes among lung cancer screening recipients with computed tomography: a systematic review.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Pooled it
- Lung cancer screening.Journal of the National Comprehensive Cancer Network : JNCCN · 2012Guideline
- Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging: the ECLS randomized controlled trial.Journal of public health (Oxford, England) · 2023Trial
- Trial
- Trial
- Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants: the NELSON study.European radiology · 2015Trial
- Cost-effectiveness of CT screening in the National Lung Screening Trial.The New England journal of medicine · 2014Trial
- Trial
- Quality of life and healthcare use in a randomized controlled lung cancer screening study.Annals of the American Thoracic Society · 2013Trial
- Trial
- [Implementation of a national lung cancer screening in Austria : Position paper of the Austrian Radiological Society (ÖRG), the Austrian Society of Pneumology (ÖGP), the Austrian Society of General Practice and Family Medicine (ÖGAM) and the Austrian Society of Thoracic Surgery (ÖGTC)].Wiener klinische Wochenschrift · 2026Article
- Lung Cancer Screening in a Population from Northeast Italy Exposed to Both Asbestos and Smoking: A Cost-Effectiveness Analysis.Journal of clinical medicine · 2026Article
- Psychological distress in patients with detected pulmonary nodules from lung cancer screening.Translational lung cancer research · 2026Article
- Personalizing lung cancer screening recommendations for heterogeneous populations: a microsimulation study.Journal of the National Cancer Institute · 2026Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn lung cancer CT screening, participants often have an indeterminate screening result at baseline requiring a follow-up CT. In subjects with either an indeterminate or a negative result after screening, we investigated whether health-related quality of life (HRQoL) changed over time and differed between groups in the short term.
methodsA total of 733 participants in the NELSON trial received four questionnaires: T0, before randomisation; T1, 1 week before the baseline screening; T2, 1 day after the screening; and T3, 2 months after the screening results but before the 3-month follow-up CT. HRQoL was measured as generic HRQoL (the 12-item Short Form, SF-12; the EuroQol questionnaire, EQ-5D), anxiety (the Spielberger State-Trait Anxiety Inventory, STAI-6), and lung-cancer-specific distress (the Impact of Event Scale, IES). For analyses, repeated-measures analysis of variance was used, adjusted for covariates.
resultsResponse to each questionnaire was 88% or higher. Scores on SF-12, EQ-5D, and STAI-6 showed no clinically relevant changes over time. At T3, IES scores that were clinically relevant increased after an indeterminate result, whereas these scores showed a significant decrease after a negative result. At T3, differences in IES scores between the two baseline result groups were both significant and clinically relevant (P<0.01).
conclusionThis longitudinal study among participants of a lung cancer screening programme showed that in the short term recipients of an indeterminate result experienced increased lung-cancer-specific distress, whereas the HRQoL changes after a negative baseline screening result may be interpreted as a relief.
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