ArticleOncogene2010
Caspase 2-mediated tumor suppression involves survivin gene silencing.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Machine Learning-Based Identification of Candidate Serum miRNA Features for Pan-Cancer and Cancer Type Classification.Life (Basel, Switzerland) · 2026Article
- Survivin/BIRC5-derived peptide disrupts survivin dimerization and cell division and induces multifaceted anti-cancer effects.Molecular therapy. Oncology · 2026Article
- Prognostic and clinicopathological significance of survivin in gynecological cancer.Oncology reviews · 2024Review
- The Role of Caspase-2 in Regulating Cell Fate.Cells · 2020Review
- Article
- Caspase-2: an orphan enzyme out of the shadows.Oncogene · 2017Review
- Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.Oncotarget · 2017Article
- NF-κB suppresses apoptosis and promotes bladder cancer cell proliferation by upregulating survivin expression in vitro and in vivo.Scientific reports · 2017Article
- Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.Cell death & disease · 2016Article
- Oncoapoptotic markers in oral cancer: prognostics and therapeutic perspective.Molecular diagnosis & therapy · 2014Review
- Targeting survivin in cancer: novel drug development approaches.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2014Review
- PIDDosome-independent tumor suppression by Caspase-2.Cell death and differentiation · 2012Article
- Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice.The Journal of biological chemistry · 2012Article
- Survivin in solid tumors: rationale for development of inhibitors.Current oncology reports · 2012Review
- Caspases and cancer.Cell death and differentiation · 2011Review
- Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.Molecular cell · 2011Article
- Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells.Cancer research · 2011Article
- Regulation of NF-κB signaling by caspases and MALT1 paracaspase.Cell research · 2011Review
- Survivin and IAP proteins in cell-death mechanisms.The Biochemical journal · 2010Review
- The role of caspase-2 in stress-induced apoptosis.Journal of cellular and molecular medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
One of the pivotal functions of endogenous tumor suppression is to oppose aberrant cell survival, but the molecular requirements of this process are not completely understood. Here, we show that caspase 2, a death effector with largely unknown functions, represses transcription of the survivin gene, a general regulator of cell division and cytoprotection in tumors. This pathway involves caspase 2 proteolytic cleavage of the nuclear factor kappaB (NFkappaB) activator, RIP1. In turn, loss of RIP1 abolishes transcription of NFkappaB target genes, including survivin, resulting in deregulated mitotic transitions, enhanced apoptosis and suppression of tumorigenicity in vivo. Therefore, caspase 2 functions as an endogenous inhibitor of NFkappaB-dependent cell survival and this mechanism may contribute to tumor suppression in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.