Evidence map›Paper›PMID 19935668›Full record

ReviewNature reviews. Molecular cell biology2009

Regulators of the cytoplasmic dynein motor.

Julia R Kardon, Ronald D Vale

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 346 papers.

0numbers the graph read from it
0cells of the map it votes in
346citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

346 citing papers in PubMed, 604 citations in OpenAlex.

  1. Article
  2. Article
  3. KIF5A and ALS: a clinical and genetic description of a case series and review of literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Frontiers in cell and developmental biology · 2026
    Article
  8. Article
  9. Exploration of the interaction between dynein intermediate chain and dynactin p150Protein science : a publication of the Protein Society · 2025
    Article
  10. Article
  11. Host-Parasite Interactions inInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

286 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Julia R KardonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Ronald D Vale
Massachusetts Institute of Technology · USUniversity of California, San Francisco · US

Funding

MICROTUBULE-BASED ORGANELLE TRANSPORTR01GM038499 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI VALE, RONALD D · 1988 to 2005
$1.2M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM038499PHS HHS 38499
6 · The paper itself

Abstract

Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse transport activities as the many different types of kinesin. How is dynein coupled to its wide range of cargos and how is it spatially and temporally regulated? The answer could lie in the several multifunctional adaptors, including dynactin, lissencephaly 1, nuclear distribution protein E (NUDE) and NUDE-like, Bicaudal D, Rod-ZW10-Zwilch and Spindly, that regulate dynein function and localization.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCytoplasmDynactin ComplexDyneinsHumansMicrotubule-Associated ProteinsAdaptor Proteins, Signal TransducingDynactin ComplexDyneinsMicrotubule-Associated Proteins

Identifiers

PMID19935668
PMCPMC3394690
OpenAlexW2115850825

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.