ArticleObstetrics and gynecology2009
Prenatal exposure to acetaminophen and asthma in children.
Article in Obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Effects of Prenatal Paracetamol Exposure on the Development of Asthma and Wheezing in Childhood: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California.International journal of environmental research and public health · 2021Article
- Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.Current environmental health reports · 2021Review
- Coronavirus in pregnancy. What we know so far?Maedica · 2020Article
- Wheezing in children: Approaches to diagnosis and management.International journal of pediatrics & adolescent medicine · 2019Review
- Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.Thorax · 2015Article
- Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children.The Journal of allergy and clinical immunology · 2015Article
- Article
- The association between acetaminophen and asthma: is there anything to learn from the upper airways?Current opinion in allergy and clinical immunology · 2014Review
- Maternal infection in pregnancy and risk of asthma in offspring.Maternal and child health journal · 2013Article
- Prenatal and perinatal analgesic exposure and autism: an ecological link.Environmental health : a global access science source · 2013Article
- Human teratogens update 2011: can we ensure safety during pregnancy?Birth defects research. Part A, Clinical and molecular teratology · 2012Review
- A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics: the INTERMAP Study.American journal of epidemiology · 2012Article
- Gestational medication use, birth conditions, and early postnatal exposures for childhood asthma.Clinical & developmental immunology · 2012Article
- Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study.Clinical epidemiology · 2012Article
- Have the efforts to prevent aspirin-related Reye's syndrome fuelled an increase in asthma?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Article
- Antibiotic exposure by 6 months and asthma and allergy at 6 years: Findings in a cohort of 1,401 US children.American journal of epidemiology · 2011Article
- Association of maternal anemia with increased wheeze and asthma in children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate whether prenatal exposure to acetaminophen is associated with risk of diagnosed asthma and asthma symptoms in children.
methodsThe authors prospectively followed 1,505 pregnant women and their children until 6 years (+/-3 months) of life. Acetaminophen use in the first and third trimesters of pregnancy was assessed before 24 weeks of gestation and within 1 month of delivery, and asthma in children was assessed when the child was 6 years old. Adjusted odds ratios (aORs) were derived from logistic regression models controlling for potential confounders.
resultsAcetaminophen was used by 69% of women during pregnancy. Use of acetaminophen did not significantly increase the risk of asthma (aOR 0.76, 95% confidence interval [CI] 0.53-1.10). Acetaminophen use during both the first and the third trimester was associated with a significantly reduced risk of asthma (aOR 0.59, 95% CI 0.36-0.98). There was no evidence of a dose response, and consumption greater than 10,400 mg (32 tablets) a month did not increase risk (aOR 0.99, 95% CI 0.19-5.30).
conclusionOur results suggest that acetaminophen use during pregnancy does not increase risk of asthma in children. LEVEL OF EVIDENCE: II.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.