Trial reportAmerican journal of physiology. Endocrinology and metabolism2010
Effect of a cyclooxygenase-2 inhibitor on postexercise muscle protein synthesis in humans.
Trial report in American journal of physiology. Endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Dietary supplement and medication use in professional and pre-professional dancers: widespread use but limited evidence of benefit-a systematic review.Frontiers in nutrition · 2026Pooled it
- A single, maximal dose of celecoxib, ibuprofen, or flurbiprofen does not reduce the muscle signalling response to plyometric exercise in young healthy adults.European journal of applied physiology · 2024Trial
- Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators.Journal of the International Society of Sports Nutrition · 2016Trial
- Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males.Journal of the International Society of Sports Nutrition · 2015Trial
- Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure.American journal of physiology. Heart and circulatory physiology · 2014Trial
- Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Trial
- Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Trial
- Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats.Journal of cachexia, sarcopenia and muscle · 2025Article
- Synergistic celecoxib and dimethyl-celecoxib combinations block cervix cancer growth through multiple mechanisms.PloS one · 2024Article
- Characterisation of the Muscle Protein Synthetic Response to Resistance Exercise in Healthy Adults: A Systematic Review and Exploratory Meta-Analysis.Translational sports medicine · 2024Review
- Postabsorptive muscle protein synthesis is higher in outpatients as compared to inpatients.American journal of physiology. Endocrinology and metabolism · 2023Article
- Multitissue responses to exercise: a MoTrPAC feasibility study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Article
- Nutritional Supplements to Support Resistance Exercise in Countering the Sarcopenia of Aging.Nutrients · 2020Review
- Clinical and biological characterization of skeletal muscle tissue biopsies of surgical cancer patients.Journal of cachexia, sarcopenia and muscle · 2019Article
- Translocation and protein complex co-localization of mTOR is associated with postprandial myofibrillar protein synthesis at rest and after endurance exercise.Physiological reports · 2018Article
- Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model.The American journal of sports medicine · 2016Article
- Prostaglandin E2/cyclooxygenase pathway in human skeletal muscle: influence of muscle fiber type and age.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Molecular Changes in Sub-lesional Muscle Following Acute Phase of Spinal Cord Injury.Neurochemical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Nonselective blockade of the cyclooxygenase (COX) enzymes in skeletal muscle eliminates the normal increase in muscle protein synthesis following resistance exercise. The current study tested the hypothesis that this COX-mediated increase in postexercise muscle protein synthesis is regulated specifically by the COX-2 isoform. Sixteen males (23 +/- 1 yr) were randomly assigned to one of two groups that received three doses of either a selective COX-2 inhibitor (celecoxib; 200 mg/dose, 600 mg total) or a placebo in double-blind fashion during the 24 h following a single bout of knee extensor resistance exercise. At rest and 24 h postexercise, skeletal muscle protein fractional synthesis rate (FSR) was measured using a primed constant infusion of [(2)H(5)]phenylalanine coupled with muscle biopsies of the vastus lateralis, and measurements were made of mRNA and protein expression of COX-1 and COX-2. Mixed muscle protein FSR in response to exercise (P < 0.05) was not suppressed by the COX-2 inhibitor (0.056 +/- 0.004 to 0.108 +/- 0.014%/h) compared with placebo (0.074 +/- 0.004 to 0.091 +/- 0.005%/h), nor was there any difference (P > 0.05) between the placebo and COX-2 inhibitor postexercise when controlling for resting FSR. The COX-2 inhibitor did not influence COX-1 mRNA, COX-1 protein, or COX-2 protein levels, whereas it did increase (P < 0.05) COX-2 mRNA (3.0 +/- 0.9-fold) compared with placebo (1.3 +/- 0.3-fold). It appears that the elimination of the postexercise muscle protein synthesis response by nonselective COX inhibitors is not solely due to COX-2 isoform blockade. Furthermore, the current data suggest that the COX-1 enzyme is likely the main isoform responsible for the COX-mediated increase in muscle protein synthesis following resistance exercise in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.