ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009
Targeting histone demethylases in cancer therapy.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Repurposing existing agents as adjunct therapies for glioblastoma.Neuro-oncology practice · 2016Article
- Development of substrate-selective probes for affinity pulldown of histone demethylases.ACS chemical biology · 2015Article
- Neuroepigenomics: Resources, Obstacles, and Opportunities.Neuroepigenetics · 2015Article
- Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection.Viruses · 2013Review
- Article
- Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer.American journal of translational research · 2012Article
- Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.Molecular cancer research : MCR · 2011Article
- The redox basis of epigenetic modifications: from mechanisms to functional consequences.Antioxidants & redox signaling · 2011Review
- Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics.Current opinion in pulmonary medicine · 2011Review
- JHDM3A module as an effector molecule in guide-directed modification of target chromatin.The Journal of biological chemistry · 2011Article
- Polycomb group proteins: New targets of anti-cancer therapy.Cell cycle (Georgetown, Tex.) · 2010Article
- HDAC inhibitors repress the polycomb protein BMI1.Cell cycle (Georgetown, Tex.) · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.