ArticleRNA (New York, N.Y.)2010
Massive expansions of Dscam splicing diversity via staggered homologous recombination during arthropod evolution.
Article in RNA (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Regulatory paradigm of Dscam1 stochastic alternative splicing through conserved long-range RNA structures.Nucleic acids research · 2026Article
- The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity.PLoS biology · 2025Article
- Following the Evolutionary Paths of Dscam1 Proteins toward Highly Specific Homophilic Interactions.Molecular biology and evolution · 2024Article
- Structure and evolution of neuronal wiring receptors and ligands.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Hidden RNA pairings counteract the "first-come, first-served" splicing principle to drive stochastic choice inScience advances · 2022Article
- Complex RNA Secondary Structures Mediate Mutually Exclusive Splicing of ColeopteraFrontiers in genetics · 2021Article
- RNA secondary structures inRNA (New York, N.Y.) · 2020Article
- Acute thiamethoxam toxicity in honeybees is not enhanced by common fungicide and herbicide and lacks stress-induced changes in mRNA splicing.Scientific reports · 2019Article
- Plasmid-based gap-repair recombineered transgenes reveal a central role for introns in mutually exclusive alternative splicing in Down Syndrome Cell Adhesion Molecule exon 4.Nucleic acids research · 2019Article
- Revisiting Dscam diversity: lessons from clustered protocadherins.Cellular and molecular life sciences : CMLS · 2019Review
- The landscape of human mutually exclusive splicing.Molecular systems biology · 2017Article
- Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing.RNA biology · 2017Article
- Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons.Nucleic acids research · 2017Article
- Article
- Improvement of Dscam homophilic binding affinity throughout Drosophila evolution.BMC evolutionary biology · 2014Article
- The evolution of Dscam genes across the arthropods.BMC evolutionary biology · 2012Article
- Innate immune complexity in the purple sea urchin: diversity of the sp185/333 system.Frontiers in immunology · 2012Article
- Widespread recurrent evolution of genomic features.Genome biology and evolution · 2012Review
- Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology.BMC bioinformatics · 2011Article
- Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster.RNA (New York, N.Y.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The arthropod Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of protein isoforms via combinatorial splicing of numerous alternative exons encoding immunoglobulin variable domains organized into three clusters referred to as the exon 4, 6, and 9 clusters. Dscam protein diversity is important for nervous system development and immune functions. We have performed extensive phylogenetic analyses of Dscam from 20 arthropods (each containing between 46 and 96 alternative exons) to reconstruct the detailed history of exon duplication and loss events that built this remarkable system over 450 million years of evolution. Whereas the structure of the exon 4 cluster is ancient, the exon 6 and 9 clusters have undergone massive, independent expansions in each insect lineage. An analysis of nearly 2000 duplicated exons enabled detailed reconstruction of the timing, location, and boundaries of these duplication events. These data clearly show that new Dscam exons have arisen continuously throughout arthropod evolution and that this process is still occurring in the exon 6 and 9 clusters. Recently duplicated regions display boundaries corresponding to a single exon and the adjacent intron. The boundaries, homology, location, clustering, and relative frequencies of these duplication events strongly suggest that staggered homologous recombination is the major mechanism by which new Dscam exons evolve. These data provide a remarkably detailed picture of how complex gene structure evolves and reveal the molecular mechanism behind this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.