ArticleRNA (New York, N.Y.)2010
Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.
Article in RNA (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 59 citations in OpenAlex.
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- Role of ROCK signaling in virus replication.Virus research · 2023Review
- Suppression of microRNA168 enhances salt tolerance in rice (Oryza sativa L.).BMC plant biology · 2022Article
- ROCK1/MLC2 inhibition induces decay of viral mRNA in BPXV infected cells.Scientific reports · 2022Article
- Enhancing the yield of seasonal influenza viruses through manipulation of microRNAs in Madin-Darby canine kidney cells.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Human La binds mRNAs through contacts to the poly(A) tail.Nucleic acids research · 2018Article
- Express: A database of transcriptome profiles encompassing known and novel transcripts across multiple development stages in eye tissues.Experimental eye research · 2018Article
- MicroRNAs recruit eIF4E2 to repress translation of target mRNAs.Protein & cell · 2017Article
- microRNAs stimulate translation initiation mediated by HCV-like IRESes.Nucleic acids research · 2017Article
- Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease.Human molecular genetics · 2015Article
- ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression.Nucleic acids research · 2015Article
- Towards a molecular understanding of microRNA-mediated gene silencing.Nature reviews. Genetics · 2015Review
- The complexity of miRNA-mediated repression.Cell death and differentiation · 2015Review
- Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.RNA (New York, N.Y.) · 2014Article
- Edc3 function in yeast and mammals is modulated by interaction with NAD-related compounds.G3 (Bethesda, Md.) · 2014Article
- A miRNA-responsive cell-free translation system facilitates isolation of hepatitis C virus miRNP complexes.RNA (New York, N.Y.) · 2013Article
- A role for eIF4AII in microRNA-mediated mRNA silencing.Nature structural & molecular biology · 2013Article
- GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation.The EMBO journal · 2013Article
- miRNA repression of translation in vitro takes place during 43S ribosomal scanning.Nucleic acids research · 2013Article
- Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally through binding specific sites within the 3' untranslated regions (UTRs) of their target mRNAs. Numerous investigations have documented repressive effects of miRNAs and identified factors required for their activity. However, the precise mechanisms by which miRNAs modulate gene expression are still obscure. Here, we have examined the effects of multiple miRNAs on diverse target transcripts containing artificial or naturally occurring 3' UTRs in human cell culture. In agreement with previous studies, we report that both the 5' m(7)G cap and 3' poly(A) tail are essential for maximum miRNA repression. These cis-acting elements also conferred miRNA susceptibility to target mRNAs translating under the control of viral- and eukaryotic mRNA-derived 5' UTR structures that enable cap-independent translation. Additionally, we evaluated a role for the poly(A)-binding protein (PABP) in miRNA function utilizing multiple approaches to modulate levels of active PABP in cells. PABP expression and activity inversely correlated with the strength of miRNA silencing, in part due to antagonism of target mRNA deadenylation. Together, these findings further define the cis- and trans-acting factors that modulate miRNA efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.