ArticleGenetics2010
The nuclear component of a cytonuclear hybrid incompatibility in Mimulus maps to a cluster of pentatricopeptide repeat genes.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 96 citations in OpenAlex.
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- RNA-sequencing Analysis of Hybrid Females Reveals a Dominance of Expression of Alleles From Outcrossing Species Over Those From Selfing Species.Genome biology and evolution · 2025Article
- Genome-wide analysis ofFrontiers in plant science · 2025Article
- Patterns of Genomic Heterogeneity in a Classic Field Cricket Mosaic Hybrid Zone.Ecology and evolution · 2024Article
- Genomic Resequencing Unravels the Genetic Basis of Domestication, Expansion, and Trait Improvement in Morus Atropurpurea.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Induction of Male Sterility by Targeted Mutation of a Restorer-of-Fertility Gene with CRISPR/Cas9-Mediated Genome Editing inPlants (Basel, Switzerland) · 2022Article
- The genomic consequences of hybridization.eLife · 2021Review
- Cytonuclear Genetic Incompatibilities in Plant Speciation.Plants (Basel, Switzerland) · 2020Review
- Interspecific Hybrids BetweenFrontiers in plant science · 2020Article
- Lethal Interaction of Nuclear and Mitochondrial Genotypes inG3 (Bethesda, Md.) · 2019Article
- Allelic Diversity of Acetyl Coenzyme A CarboxylaseInternational journal of molecular sciences · 2019Article
- Linkage Mapping and Genome-Wide Association Studies of theFrontiers in genetics · 2019Article
- Hybridization, sex-specific genomic architecture and local adaptation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Speciation genes are more likely to have discordant gene trees.Evolution letters · 2018Article
- In Silico Identification of Candidate Genes for Fertility Restoration in Cytoplasmic Male Sterile Perennial Ryegrass (Lolium perenne L.).Genome biology and evolution · 2017Article
- Mitochondrial-nuclear co-evolution leads to hybrid incompatibility through pentatricopeptide repeat proteins.EMBO reports · 2017Article
- Genetic conflicts: the usual suspects and beyond.The Journal of experimental biology · 2017Review
- Selfish evolution of cytonuclear hybrid incompatibility in Mimulus.Proceedings. Biological sciences · 2016Article
- Genomic Conflicts that Cause Pollen Mortality and Raise Reproductive Barriers in Arabidopsis thaliana.Genetics · 2016Article
- Correlated polymorphism in cytotype and sexual system within a monophyletic species, Lycium californicum.Annals of botany · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterizing the genetic and molecular basis of hybrid incompatibilities is a first step toward understanding their evolutionary origins. We fine mapped the nuclear restorer (Rf) of cytoplasm-dependent anther sterility in Mimulus hybrids by identifying and targeting regions of the Mimulus guttatus genome containing large numbers of candidate pentatricopeptide repeat genes (PPRs). The single Mendelian locus Rf was first isolated to a 1.3-cM region on linkage group 7 that spans the genome's largest cluster of PPRs, then split into two tightly linked loci (Rf1 and Rf2) by <10 recombination events in a large (N = 6153) fine-mapping population. Progeny testing of fertile recombinants demonstrated that a dominant M. guttatus allele at each Rf locus was sufficient to restore fertility. Each Rf locus spans a physical region containing numerous PPRs with high homology to each other, suggesting recent tandem duplication or transposition. Furthermore, these PPRs have higher homology to restorers in distantly related taxa (petunia and rice) than to PPRs elsewhere in the Mimulus genome. These results suggest that the cytoplasmic male sterility (CMS)-PPR interaction is highly conserved across flowering plants. In addition, given our theoretical understanding of cytonuclear coevolution, the finding that hybrid CMS results from interactions between a chimeric mitochondrial transcript that is modified by Rf loci identified as PPRs is consistent with a history of selfish mitochondrial evolution and compensatory nuclear coevolution within M. guttatus.
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