ArticleInfection and immunity2010
Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 58 citations in OpenAlex.
- TLR Signaling Beyond Immunity: Emerging Roles in Cell Migration, Metabolism, Development, and Host-Microbiome Crosstalk.Biology · 2026Review
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- Pathophysiological and Clinical Potential of Human Microbiome: Microbe-based Therapeutic Insights.Current pharmaceutical biotechnology · 2025Review
- Arresting microbiome development limits immune system maturation and resistance to infection in mice.Cell host & microbe · 2023Article
- Oral biofilm dysbiosis during experimental periodontitis.Molecular oral microbiology · 2022Article
- Effects of Milk Replacer-BasedMicrobiology spectrum · 2022Article
- ToxT Regulon Is Nonessential for Vibrio cholerae Colonization in Adult Mice.Applied and environmental microbiology · 2022Article
- A Mouse Periodontitis Model With Humanized Oral Bacterial Community.Frontiers in cellular and infection microbiology · 2022Article
- Episymbiotic Saccharibacteria suppresses gingival inflammation and bone loss in mice through host bacterial modulation.Cell host & microbe · 2021Article
- Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life.Mucosal immunology · 2021Article
- Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection.Frontiers in cellular and infection microbiology · 2021Review
- Analysis of infant microbiota composition and the relationship with breast milk components in the Asian elephant (Elephas maximus) at the zoo.The Journal of veterinary medical science · 2020Article
- Early-Life Microbiota Exposure Restricts Myeloid-Derived Suppressor Cell-Driven Colonic Tumorigenesis.Cancer immunology research · 2019Article
- Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.EMBO reports · 2019Article
- Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.Mucosal immunology · 2019Review
- The microbiota protects against respiratory infection via GM-CSF signaling.Nature communications · 2017Article
- Neonatal acquisition ofScience (New York, N.Y.) · 2017Article
- The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior.Molecular psychiatry · 2017Article
- TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens.Molecular oral microbiology · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Commensal bacteria possess immunostimulatory activities that can modulate host responses to affect development and homeostasis in the intestine. However, how different populations of resident bacteria stimulate the immune system remains largely unknown. We characterized here the ability of intestinal and oral microflora to stimulate individual pattern recognition receptors (PRRs) in bone marrow-derived macrophages and mesothelial cells. The intestinal but not oral microflora elicited age- and cell type-specific immunostimulation. The immunostimulatory activity of the intestinal microflora varied among individual mice but was largely mediated via Toll-like receptor 4 (TLR4) during breast-feeding, whereas it became TLR4 independent after weaning. This transition was associated with a change from a microflora rich in TLR4-stimulatory proteobacteria to one dominated by Bacteroidales and/or Clostridiales that poorly stimulate TLR4. The major stimulatory activity of the intestinal microflora was still intact in NOD1-, NOD2-, TLR2-, TLR4-, TLR5-, TLR9-, TLR11-, ASC-, or RICK-deficient cells but still relied on the adaptor MyD88. These studies demonstrate a transition in the intestinal microflora accompanied by a dynamic change of its ability to stimulate different PRRs which control intestinal homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.