ArticleNucleic acids research2010
EuroPhenome: a repository for high-throughput mouse phenotyping data.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The influence of rare variants in circulating metabolic biomarkers.PLoS genetics · 2020Pooled it
- Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.PLoS genetics · 2014Pooled it
- Behavioral characterization of a novel Cisd2 mutant mouse.Behavioural brain research · 2021Article
- Reproducibility and replicability of rodent phenotyping in preclinical studies.Neuroscience and biobehavioral reviews · 2018Review
- FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination.PLoS genetics · 2018Article
- Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse.ILAR journal · 2017Review
- INFRAFRONTIER: a European resource for studying the functional basis of human disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.FEBS letters · 2016Article
- Mouse genome database 2016.Nucleic acids research · 2016Article
- A mouse informatics platform for phenotypic and translational discovery.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.Nature genetics · 2015Article
- Mouse Genome Database: From sequence to phenotypes and disease models.Genesis (New York, N.Y. : 2000) · 2015Review
- The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.Human molecular genetics · 2015Article
- A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines.Genome research · 2015Article
- Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens.Journal of biomedical semantics · 2015Article
- The scientific quest for lasting youth: prospects for curing aging.Rejuvenation research · 2014Article
- Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model.BMC medical genomics · 2014Article
- The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.Nucleic acids research · 2014Article
- Commentary on Shimoyama et al. (2012): three ontologies to define phenotype measurement data.Frontiers in genetics · 2014Article
- Ensembl 2014.Nucleic acids research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data arising from projects such as EUMODIC. EUMODIC is gathering data from the EMPReSSslim pipeline (http://www.empress.har.mrc.ac.uk/) which is performed on inbred mouse strains and knock-out lines arising from the EUCOMM project. The EuroPhenome interface allows the user to access the data via the phenotype or genotype. It also allows the user to access the data in a variety of ways, including graphical display, statistical analysis and access to the raw data via web services. The raw phenotyping data captured in EuroPhenome is annotated by an annotation pipeline which automatically identifies statistically different mutants from the appropriate baseline and assigns ontology terms for that specific test. Mutant phenotypes can be quickly identified using two EuroPhenome tools: PhenoMap, a graphical representation of statistically relevant phenotypes, and mining for a mutant using ontology terms. To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.