ArticleClinical trials (London, England)2009
Involving American Indians and medically underserved rural populations in cancer clinical trials.
Article in Clinical trials (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Quantifying Sample Representation in Global Pharmacogenomic Studies of Major Depressive Disorder: A Systematic Review.Clinical and translational science · 2025Pooled it
- Electronic Health Record-Driven Approaches in Primary Care to Strengthen Hypertension Management Among Racial and Ethnic Minoritized Groups in the United States: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Pooled it
- Systematic Review and Meta-Analysis of the Magnitude of Structural, Clinical, and Physician and Patient Barriers to Cancer Clinical Trial Participation.Journal of the National Cancer Institute · 2019Pooled it
- Strategies addressing barriers to clinical trial enrollment of underrepresented populations: a systematic review.Contemporary clinical trials · 2014Pooled it
- Empowering Latina breast cancer patients to make informed decisions about clinical trials: a pilot study.Translational behavioral medicine · 2018Trial
- Coaching intervention as a strategy for minority recruitment to cancer clinical trials.Journal of oncology practice · 2013Trial
- Cancer clinical trial recruitment for patients from rural areas: a scoping review.International journal for equity in health · 2026Article
- A reservation-based clinical trial on inflammatory biomarkers in American Indian/Alaska Native cancer patients: Rationale and design of the Adaptive Prehab Approaches in Cancer Healing and Education (APACHE) Program.Contemporary clinical trials · 2026Article
- Hidden in the Data: Breast Cancer Patterns, Gaps, and Challenges for Native American Women.Current breast cancer reports · 2026Review
- Article
- Enrollment of underserved racial and ethnic populations in pediatric asthma clinical trials.The journal of allergy and clinical immunology. Global · 2024Article
- Promoting equity in clinical research: The role of social determinants of health.Journal of biomedical informatics · 2024Article
- Community engagement through social media: A promising low-cost strategy for rural recruitment?The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2024Article
- Health Behavior Change Intervention Preferences Expressed by American Indian Cancer Survivors From a Southwest Tribal Community: Semistructured Interview Study.JMIR formative research · 2024Article
- Leveraging Social Determinants of Health to Enhance Recruitment of Underrepresented Populations in Clinical Trials.Methodist DeBakey cardiovascular journal · 2024Review
- Community Engagement Strategies for Underrepresented Racial and Ethnic Populations.Mayo Clinic proceedings · 2024Review
- Opportunities to Increase Science of Diversity and Inclusion in Clinical Trials: Equity and a Lack of a Control.Journal of the American Heart Association · 2023Review
- The National Cancer Institute's Cancer Disparities Research Partnership Program: a unique funding model 20 years later.Journal of the National Cancer Institute · 2023Article
- Feasibility and Utility of a Pilot Peer Education Program to Improve Patient Engagement in Lupus Clinical Trials: Implementation and Evaluation in a Multisite Model Within a Lupus Clinical Trials Network.ACR open rheumatology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess cancer clinical trial recruitment and reasons for nonaccrual among a rural, medically underserved population served by a community-based cancer care center.
methodsWe prospectively tracked clinical trial enrollment incidence among all new patients presenting at the Rapid City Regional Cancer Care Institute. Evaluating physicians completed questionnaires for each patient regarding clinical trial enrollment status and primary reasons for nonenrollment. Patients who identified as American Indian were referred to a program where patients were assisted in navigating the medical system by trained, culturally competent staff.
resultsBetween September 2006 and January 2008, 891 new cancer patients were evaluated. Seventy-eight patients (9%; 95% confidence intervals, 7-11%) were enrolled on a clinical treatment trial. For 73% (95% confidence intervals, 69-75%) of patients (646 of 891) lack of relevant protocol availability or protocol inclusion criteria restrictiveness was the reason for nonenrollment. Only 45 (5%; 95% confidence intervals, 4-7%) patients refused enrollment on a trial. Of the 78 enrolled on a trial, 6 (8%; 95% confidence intervals, 3-16%) were American Indian. Three additional American Indian patients were enrolled under a nontreatment cancer control trial, bringing the total percentage enrolled of the 94 American Indians who presented to the clinic to 10% (95% confidence intervals, 5-17%). LIMITATIONS: Eligibility rates were unable to be calculated and cross validation of the number in the cohort via registries or ICD-9 codes was not performed.
conclusionClinical trial participation in this medically underserved population was low overall, but approximately 3-fold higher than reported national accrual rates. Lack of availability of protocols for common cancer sites as well as stringent protocol inclusion criteria were the primary obstacles to clinical trial enrollment. Targeted interventions using a Patient Navigation program were used to engage AI patients and may have resulted in higher clinical trial enrollment among this racial/ethnic group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.