ArticleCirculation. Heart failure2010
Impact of HIV infection on diastolic function and left ventricular mass.
Article in Circulation. Heart failure, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 120 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
Register of Cardiovascular Complications Among People Living With HIV
Changes in Weight and Body Composition After Switch to Dolutegravir/Lamivudine Compared to Continued Dolutegravir/Abacavir/Lamivudine for Virologically Suppressed HIV Infection: A Randomized Open-label Superiority Trial: AVERTAS-1
Who cites it
120 citing papers in PubMed, 204 citations in OpenAlex.
- Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study.The Journal of infectious diseases · 2024Trial
- Trial
- Statin therapy decreases N-terminal pro-B-type natriuretic peptide in HIV: randomized placebo-controlled trial.AIDS (London, England) · 2015Trial
- Trial
- Cardiovascular risk factors and cardiac dysfunction in people with HIV and breast cancer: an observational cohort study in Botswana.Cardio-oncology (London, England) · 2026Article
- Evaluation of Cardiac Findings in People With Human Immunodeficiency Virus.Anatolian journal of cardiology · 2025Article
- Arterial stiffness in people with HIV: a cross-sectional, comparative study with echocardiographic outcomes in Tanzania.AIDS (London, England) · 2025Article
- Article
- Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure.Nature communications · 2025Article
- Predictors of echocardiographic abnormalities among people living with hiv on anti-retroviral therapy in Kumasi, Ghana.BMC infectious diseases · 2024Article
- Prevalence and predictors of right ventricular dysfunction among adults living with HIV in northwest Nigeria.Cardiovascular diagnosis and therapy · 2024Article
- Depressive Symptoms and Left Ventricular Diastolic Dysfunction Among Men and Women with HIV.European Medical Journal. Cardiology · 2024Article
- Article
- Prevalence and patterns of echocardiographic abnormalities among people living with HIV on anti-retroviral therapy in Kumasi, Ghana.BMC cardiovascular disorders · 2024Article
- Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection.Scientific reports · 2024Article
- Association of Coronary Wall Thickening and Diminished Diastolic Function in Asymptomatic, Low Cardiovascular Disease-Risk Persons Living with HIV.Radiology. Cardiothoracic imaging · 2024Observational
- Unveiling Subclinical Cardiovascular Disease in HIV with Advanced Cardiovascular Imaging.Radiology. Cardiothoracic imaging · 2024Article
- Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study.medRxiv : the preprint server for health sciences · 2023Article
- Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV.Journal of the American Heart Association · 2023Article
- Antiretroviral Therapy Ameliorates Simian Immunodeficiency Virus-Associated Myocardial Inflammation by Dampening Interferon Signaling and Pathogen Response in the Heart.The Journal of infectious diseases · 2023Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPatients with HIV have increased risk for cardiovascular disease, but the underlying mechanisms remain unknown. The purpose of this study was to determine the prevalence of echocardiographic abnormalities among asymptomatic HIV-infected individuals compared with HIV-uninfected individuals. Methods/Results- We performed echocardiography in 196 HIV-infected adults and 52 controls. Left ventricular ejection fraction, left ventricular mass indexed to the body surface area, and diastolic function were assessed according to American Society of Echocardiography standards. Left ventricular mass index was higher in HIV-infected patients (77.2 g/m(2) in patients with HIV versus 66.5 g/m(2) in controls, P<0.0001). Left ventricular ejection fraction was similar in both groups. Eight (4%) of the patients with HIV had evidence of left ventricular systolic dysfunction (defined as an EF <50%) versus none of the controls; 97 (50%) had mild diastolic dysfunction compared with 29% of the HIV-uninfected subjects (P=0.008). After adjustment for hypertension and race, HIV-infected participants had a mean 8 g/m(2) larger left ventricular mass index compared with controls (P=0.001). Higher left ventricular mass index was independently associated with lower nadir CD4 T-cell count, suggesting that immunodeficiency may play a role in this process. After adjustment for age and traditional risk factors, patients with HIV had a 2.4 greater odds of having diastolic dysfunction as compared with controls (P=0.019).
conclusionsHIV-infected patients had a higher prevalence of diastolic dysfunction and higher left ventricular mass index compared with controls. These differences were not readily explained by differences in traditional risk factors and were independently associated with HIV infection. These results suggest that contemporary asymptomatic patients with HIV manifest mild functional and morphological cardiac abnormalities, which are independently associated with HIV infection.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.