ArticleThe Journal of biological chemistry2010
AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Role of SIRT3 in the regulation of Gadd45α expression and DNA repair in β-cells.The Journal of biological chemistry · 2025Article
- ABA-GA antagonism and modular gene networks cooperatively drive acquisition of desiccation tolerance in perilla seeds.Frontiers in plant science · 2025Article
- β-Cell-selective regulation of gene expression by nitric oxide.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells.Function (Oxford, England) · 2022Article
- AMPK Activity: A Primary Target for Diabetes Prevention with Therapeutic Phytochemicals.Nutrients · 2021Review
- The location of sensing determines the pancreatic β-cell response to the viral mimetic dsRNA.The Journal of biological chemistry · 2020Article
- The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide.Molecular and cellular biology · 2019Article
- Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system.Journal of neurochemistry · 2019Article
- Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage.Antioxidants & redox signaling · 2018Review
- Article
- Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response.Molecular and cellular biology · 2016Article
- Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation.Scientific reports · 2016 · on this mapArticle
- An extract of Artemisia dracunculus L. stimulates insulin secretion from β cells, activates AMPK and suppresses inflammation.Journal of ethnopharmacology · 2015Article
- Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability.Cell death & disease · 2015Article
- Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells.Stem cells translational medicine · 2015Article
- Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells.The Journal of biological chemistry · 2014Article
- Leptin regulates KATP channel trafficking in pancreatic β-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA).The Journal of biological chemistry · 2013Article
- The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.Annals of the New York Academy of Sciences · 2013Review
- Differential responses of pancreatic β-cells to ROS and RNS.American journal of physiology. Endocrinology and metabolism · 2013Article
- Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice.Endocrinology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
During the initial autoimmune response in type 1 diabetes, islets are exposed to a damaging mix of pro-inflammatory molecules that stimulate the production of nitric oxide by beta-cells. Nitric oxide causes extensive but reversible cellular damage. In response to nitric oxide, the cell activates pathways for functional recovery and adaptation as well as pathways that direct beta-cell death. The molecular events that dictate cellular fate following nitric oxide-induced damage are currently unknown. In this study, we provide evidence that AMPK plays a primary role controlling the response of beta-cells to nitric oxide-induced damage. AMPK is transiently activated by nitric oxide in insulinoma cells and rat islets following IL-1 treatment or by the exogenous addition of nitric oxide. Active AMPK promotes the functional recovery of beta-cell oxidative metabolism and abrogates the induction of pathways that mediate cell death such as caspase-3 activation following exposure to nitric oxide. Overall, these data show that nitric oxide activates AMPK and that active AMPK suppresses apoptotic signaling allowing the beta-cell to recover from nitric oxide-mediated cellular stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.