ArticleGenes & development2009
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Genomic context sensitizes regulatory elements to genetic disruption.Molecular cell · 2024Article
- Genomic context sensitizes regulatory elements to genetic disruption.bioRxiv : the preprint server for biology · 2024Article
- Activating and repressing gene expression between chromosomes during stochastic fate specification.Cell reports · 2023Article
- Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.Nature communications · 2022Article
- MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells.Nucleic acids research · 2020Article
- WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating.Nature genetics · 2019Article
- Molecular basis and biological function of variability in spatial genome organization.Science (New York, N.Y.) · 2019Review
- A new approach of gene co-expression network inference reveals significant biological processes involved in porcine muscle development in late gestation.Scientific reports · 2018Article
- Does cross-generational epigenetic inheritance contribute to cultural continuity?Environmental epigenetics · 2018Article
- Enhancer functions in three dimensions: beyond the flat world perspective.F1000Research · 2018Review
- Article
- Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells.BMC cell biology · 2016Article
- Prenatal molecular testing for Beckwith-Wiedemann and Silver-Russell syndromes: a challenge for molecular analysis and genetic counseling.European journal of human genetics : EJHG · 2016Review
- Article
- Three Dimensional Organization of Genome Might Have Guided the Dynamics of Gene Order Evolution in Eukaryotes.Genome biology and evolution · 2016Article
- Pairing and anti-pairing: a balancing act in the diploid genome.Current opinion in genetics & development · 2016Review
- Genetics of Common Endocrine Disease: The Present and the Future.The Journal of clinical endocrinology and metabolism · 2016Review
- Epigenetics and inheritance of phenotype variation in livestock.Epigenetics & chromatin · 2016Review
- Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.Cell stem cell · 2015Article
- Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.Nucleic acids research · 2014Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
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