ArticleJournal of structural biology2010
Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins.
Article in Journal of structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 59 citations in OpenAlex.
- Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms.Toxins · 2025Article
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- Insights into the Evolutionary Dynamics: Characterization of Disintegrin and Metalloproteinase Proteins in the Venom Gland Transcriptome of theProtein and peptide letters · 2024Article
- Snake venom gene expression is coordinated by novel regulatory architecture and the integration of multiple co-opted vertebrate pathways.Genome research · 2022Article
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- Snake Venom Metalloproteinases (SVMPs): A structure-function update.Toxicon: X · 2020Review
- ADAM proteases: Emerging role and targeting of the non-catalytic domains.Cancer letters · 2019Review
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- Coralsnake Venomics: Analyses of Venom Gland Transcriptomes and Proteomes of Six Brazilian Taxa.Toxins · 2017Article
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- An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.The Journal of experimental medicine · 2016Article
- Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics.Molecular & cellular proteomics : MCP · 2016Article
- ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.Toxins · 2016Review
- Review
- Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah).BMC genomics · 2015Article
- RNA-seq and high-definition mass spectrometry reveal the complex and divergent venoms of two rear-fanged colubrid snakes.BMC genomics · 2014Article
- Therapeutic potential of snake venom in cancer therapy: current perspectives.Asian Pacific journal of tropical biomedicine · 2013Review
- Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function.Journal of cell science · 2012Article
- A smallest 6 kda metalloprotease, mini-matrilysin, in living world: a revolutionary conserved zinc-dependent proteolytic domain- helix-loop-helix catalytic zinc binding domain (ZBD).Journal of biomedical science · 2012Article
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8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The structures of snake venom metalloproteases (SVMPs) are proposed to be useful models to understand the structural and functional relationship of ADAM (a disintegrin and metalloprotease) which are membrane-anchored proteins involved in multiple human diseases. We have purified, sequenced and determined the structures of two new P-III SVMPs - atragin and kaouthiagin-like (K-like) from Naja atra. Atragin exhibits a known C-shaped topology, whereas K-like adopts an I-shaped conformation because of the distinct disulfide pattern in the disintegrin-like (D) domain. K-like exhibits an enzymatic specificity toward pro-TNFalpha with less inhibition of cell migration, but atragin shows the opposite effect. The specificity of the enzymatic activity is indicated to be dominated mainly by the local structures of SVMP in the metalloprotease (M) domain, whereas the hyper-variable region (HVR) in the cysteine-rich (C) domain is involved in a cell-migration activity. We demonstrate also a pH-dependent enzymatic activity of atragin that we correlate with the structural dynamics of a Zn(2+)-binding motif and the Met-turn based on the structures determined with a pH-jump method. The structural variations between the C- and I-shapes highlight the disulfide bond patterns in the D domain of the ADAM/adamalysin/reprolysins family proteins.
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