ReviewPhotodiagnosis and photodynamic therapy
Photodynamic therapy for localized infections--state of the art.
Review in Photodiagnosis and photodynamic therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07494773 (Topical Methylene Blue-Photodynamic Therapy), which is not on this map. Cited by 229 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection: A Prospective Randomized Pilot Study
Who cites it
229 citing papers in PubMed, 4 syntheses or guidelines pooled it, 770 citations in OpenAlex.
- Antimicrobial photodynamic therapy mediated by phenothiazine photosensitizers against Candida albicans and Candida auris: a systematic review.Lasers in medical science · 2026Pooled it
- Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- The effects of repeated applications of antimicrobial photodynamic therapy in the treatment of residual periodontal pockets: a systematic review.Lasers in medical science · 2019Pooled it
- A combination of photodynamic therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2019Pooled it
- Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial.World journal of experimental medicine · 2026Trial
- Preoperative irrigation and vacuum sealing drainage with antibiotic-containing drainage fluid of foot and ankle wounds improves outcome of reconstructive skin flap surgery.Journal of orthopaedic surgery and research · 2019Trial
- Polymeric Nanoparticle-Based Photodynamic Therapy for Chronic Periodontitis in Vivo.International journal of molecular sciences · 2016Trial
- Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial.Photomedicine and laser surgery · 2014Trial
- Photodynamic antimicrobial and antineoplastic therapy in veterinary medicine: current status, challenges, and perspectives.The veterinary quarterly · 2026Review
- Laparoscopic Methylene Blue Photodynamic Therapy for Intraabdominal Infection: A Preclinical Feasibility Study in a Rabbit Model of Perforated Appendicitis.Lasers in surgery and medicine · 2026Article
- Hydralazine potentiates the antiproliferative effect of photodynamic therapy on Candida albicans and Candida parapsilosis in vitro.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Recent Advances in Zinc(II)-Complexes for Antibacterial Photodynamic Therapy.Chemistry, an Asian journal · 2026Review
- Advances in carrier-free nanodrug delivery systems.Drug delivery and translational research · 2026Review
- An in vitro comparison of cold atmospheric plasma and methylene blue-mediated antimicrobial photodynamic therapy with 660 nm laser on Streptococcus mutans biofilms.Lasers in medical science · 2026Article
- Investigating the Efficacy of Various Photosensitizers and Irradiation Strategies in Antimicrobial Photodynamic Inactivation on Different Types of Microbes.International journal of molecular sciences · 2026Article
- Experiences and theory reveal a decrease in antimicrobial blue light killing efficiency as biofilm grows in a Pseudomonas aeruginosa model.Scientific reports · 2026Article
- Photodynamic Therapy in Dermatology.International journal of molecular sciences · 2026Review
- Siderophore-Porphyrin conjugates for bacteria-selective antimicrobial photodynamic therapy.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Magnesium phosphate mineralized Ce6 composite hydrogel with photodynamic therapy-mediated antibacterial, anti-inflammatory, and pro-angiogenic properties for application in infected wound healing.Materials today. Bio · 2026Article
- Calcium Phosphate Bone Substitutes in the Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw: A Review.Journal of functional biomaterials · 2026Review
169 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Photodynamic therapy (PDT) was discovered over 100 years ago by observing the killing of microorganisms when harmless dyes and visible light were combined in vitro. Since then it has primarily been developed as a treatment for cancer, ophthalmologic disorders and in dermatology. However, in recent years interest in the antimicrobial effects of PDT has revived and it has been proposed as a therapy for a large variety of localized infections. This revival of interest has largely been driven by the inexorable increase in drug resistance among many classes of pathogen. Advantages of PDT include equal killing effectiveness regardless of antibiotic resistance, and a lack of induction of PDT resistance. Disadvantages include the cessation of the antimicrobial effect when the light is turned off, and less than perfect selectivity for microbial cells over host tissue. This review will cover the use of PDT to kill or inactivate pathogens in ex vivo tissues and in biological materials such as blood. PDT has been successfully used to kill pathogens and even to save life in several animal models of localized infections such as surface wounds, burns, oral sites, abscesses and the middle ear. A large number of clinical studies of PDT for viral papillomatosis lesions and for acne refer to its antimicrobial effect, but it is unclear how important this microbial killing is to the overall therapeutic outcome. PDT for periodontitis is a rapidly growing clinical application and other dental applications are under investigation. PDT is being clinically studied for other dermatological infections such as leishmaniasis and mycobacteria. Antimicrobial PDT will become more important in the future as antibiotic resistance is only expected to continue to increase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.