ArticleNeuroscience2010
State-dependent plasticity of the corticostriatal pathway.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures.Frontiers in neurology · 2021Pooled it
- Optimizing Cognitive Training for the Treatment of Cognitive Dysfunction in Parkinson's Disease: Current Limitations and Future Directions.Frontiers in aging neuroscience · 2021Review
- Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights.Journal of neuroscience methods · 2016Article
- Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays.Journal of neuroscience methods · 2015Article
- Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.Frontiers in cellular neuroscience · 2015Article
- Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates.Journal of neurophysiology · 2013Article
- Corticostriatal connectivity and its role in disease.Nature reviews. Neuroscience · 2013Review
- Dopaminergic modulation of striatal neurons, circuits, and assemblies.Neuroscience · 2011Review
- Neuromodulatory control of striatal plasticity and behavior.Current opinion in neurobiology · 2011Review
- Article
- Modulation of striatal projection systems by dopamine.Annual review of neuroscience · 2011Review
- The role of dopamine in modulating the structure and function of striatal circuits.Progress in brain research · 2010Article
- Spike-timing-dependent plasticity in the intact brain: counteracting spurious spike coincidences.Frontiers in synaptic neuroscience · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Plasticity at corticostriatal synapses is thought to underlie both normal and aberrant forms of reinforcement-driven learning. Studies in brain slices have found bidirectional, spike-timing dependent plasticity in striatum; however it is not known whether similar rules govern corticostriatal plasticity in awake behaving animals. To assess whether behavioral state is a key regulator of plasticity in this pathway, we examined the effects of 5 Hz cortical stimulation trains on evoked striatal field potentials, in either anesthetized or awake, unrestrained rats. Consistent with prior studies we observed long-term potentiation in intact, barbiturate-anesthetized animals. However, when an identical stimulation pattern was applied to the same animals while awake, long-term depression was observed instead. Our results demonstrate that the rules governing corticostriatal plasticity depend critically on behavioral state, and suggest that the dynamic context of cortical-basal ganglia loops must be considered while investigating synaptic mechanisms underlying reinforcement learning and neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.