ReviewFEBS letters2009
Modularity and design principles in the sea urchin embryo gene regulatory network.
Review in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis.bioRxiv : the preprint server for biology · 2025Article
- Anterior-Posterior Wnt Signaling Network Conservation between Indirect Developing Sea Urchin and Hemichordate Embryos.Integrative and comparative biology · 2024Article
- Article
- Recombinant SpTransformer proteins bind to specific sites on sea urchin phagocytes and modulateFrontiers in immunology · 2024Article
- Lhx3/4 initiates a cardiopharyngeal-specific transcriptional program in response to widespread FGF signaling.PLoS biology · 2024Article
- Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells.Frontiers in immunology · 2023Review
- Article
- Conditional specification of endomesoderm.Cells & development · 2021Review
- Article
- Assessing regulatory information in developmental gene regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A cell-based computational model of early embryogenesis coupling mechanical behaviour and gene regulation.Nature communications · 2017Article
- Eric Davidson: Steps to a gene regulatory network for development.Developmental biology · 2016Article
- Understanding transcriptional regulatory networks using computational models.Current opinion in genetics & development · 2016Review
- Robustness and Accuracy in Sea Urchin Developmental Gene Regulatory Networks.Frontiers in genetics · 2016Article
- Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mechanisms of mutational robustness in transcriptional regulation.Frontiers in genetics · 2015Review
- Using giant scarlet runner bean embryos to uncover regulatory networks controlling suspensor gene activity.Frontiers in plant science · 2015Article
- Modeling Scalable Pattern Generation in DNA Reaction Networks.Natural computing · 2014Article
- General approach for in vivo recovery of cell type-specific effector gene sets.Genome research · 2014Article
- Encoding regulatory state boundaries in the pregastrular oral ectoderm of the sea urchin embryo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The gene regulatory network (GRN) established experimentally for the pre-gastrular sea urchin embryo provides causal explanations of the biological functions required for spatial specification of embryonic regulatory states. Here we focus on the structure of the GRN which controls the progressive increase in complexity of territorial regulatory states during embryogenesis; and on the types of modular subcircuits of which the GRN is composed. Each of these subcircuit topologies executes a particular operation of spatial information processing. The GRN architecture reflects the particular mode of embryogenesis represented by sea urchin development. Network structure not only specifies the linkages constituting the genomic regulatory code for development, but also indicates the various regulatory requirements of regional developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.