ArticleNeuroscience2010
AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The Signaling and Pharmacology of the Dopamine D1 Receptor.Frontiers in cellular neuroscience · 2021Pooled it
- The role of motivation in eating disorders: understanding sex differences in the circuits.Frontiers in behavioral neuroscience · 2025Review
- Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings.Addiction neuroscience · 2024Article
- AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain.Molecular brain · 2021Article
- Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens.Physiology & behavior · 2020Review
- Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs.Current pharmaceutical design · 2020Article
- Intracranial Pharmacotherapy and Pain Assays in Rodents.Journal of visualized experiments : JoVE · 2019Article
- Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring.BioMed research international · 2018Review
- Augmentation of Heroin Seeking Following Chronic Food Restriction in the Rat: Differential Role for Dopamine Transmission in the Nucleus Accumbens Shell and Core.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Food restriction induces synaptic incorporation of calcium-permeable AMPA receptors in nucleus accumbens.The European journal of neuroscience · 2017Article
- AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain.Anesthesiology · 2016Article
- Effects of food restriction on expression of place conditioning and biochemical correlates in rat nucleus accumbens.Psychopharmacology · 2016Article
- Nucleus Accumbens AMPA Receptor Trafficking Upregulated by Food Restriction: An Unintended Target for Drugs of Abuse and Forbidden Foods.Current opinion in behavioral sciences · 2016Article
- Insulin receptor activation in the nucleus accumbens reflects nutritive value of a recently ingested meal.Physiology & behavior · 2016Article
- Increased intravenous morphine self-administration following Roux-en-Y gastric bypass in dietary obese rats.Brain research bulletin · 2016Article
- Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens.Molecular brain · 2015Article
- Nucleus accumbens AMPA receptor involvement in cocaine-conditioned place preference under different dietary conditions in rats.Psychopharmacology · 2015Article
- Article
- Involvement of nucleus accumbens AMPA receptor trafficking in augmentation of D- amphetamine reward in food-restricted rats.Psychopharmacology · 2014Article
- Ca2+-permeable AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors and dopamine D1 receptors regulate GluA1 trafficking in striatal neurons.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Previous findings suggest that neuroadaptations downstream of D-1 dopamine (DA) receptor stimulation in nucleus accumbens (NAc) are involved in the enhancement of drug reward by chronic food restriction (FR). Given the high co-expression of D-1 and GluR1 AMPA receptors in NAc, and the regulation of GluR1 channel conductance and trafficking by D-1-linked intracellular signaling cascades, the present study examined effects of the D-1 agonist, SKF-82958, on NAc GluR1 phosphorylation, intracranial electrical self-stimulation reward (ICSS), and reversibility of reward effects by a polyamine GluR1 antagonist, 1-NA-spermine, in ad libitum fed (AL) and FR rats. Systemically administered SKF-82958, or brief ingestion of a 10% sucrose solution, increased NAc GluR1 phosphorylation on Ser845, but not Ser831, with a greater effect in FR than AL rats. Microinjection of SKF-82958 in NAc shell produced a reward-potentiating effect that was greater in FR than AL rats, and was reversed by co-injection of 1-NA-spermine. GluR1 abundance in whole cell and synaptosomal fractions of NAc did not differ between feeding groups, and microinjection of AMPA, while affecting ICSS, did not exert greater effects in FR than AL rats. These results suggest a role of NAc GluR1 in the reward-potentiating effect of D-1 DA receptor stimulation and its enhancement by FR. Moreover, GluR1 involvement appears to occur downstream of D-1 DA receptor stimulation rather than reflecting a basal increase in GluR1 expression or function. Based on evidence that phosphorylation of GluR1 on Ser845 primes synaptic strengthening, the present results may reflect a mechanism via which FR normally facilitates reward-related learning to re-align instrumental behavior with environmental contingencies under the pressure of negative energy balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.