Evidence map›Paper›PMID 19931542›Full record

ArticleJournal of molecular and cellular cardiology2010

An antidote for calcium leak: targeting molecular arrhythmia mechanisms.

Stephan E Lehnart, W J Lederer

Registry-linked trialOpen access · greenAbstract readCommentEditorial
PubMed Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01209494 (The EU TrigTreat Clinical Study), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01209494 completednot on this map

The EU TrigTreat Clinical Study: An Advanced Diagnostics and Observational Trial for Arrhythmia Risk Stratification and Correlation With Genotype

TypeobservationalSponsorUniversity Medical Center GoettingenRan2010 to 2014Enrolled672ConditionsCardiomyopathies, Primary, Arrhythmia, Sudden Cardiac Death, Calcium Metabolism Disorders
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. How does flecainide impact RyR2 channel function?The Journal of general physiology · 2022
    Article
  2. Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2012
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stephan E Lehnart
W J Lederer
University of Maryland, Baltimore · USUniversity of Maryland Medical Center · US

Funding

Molecular Basis of Sudden Cardiac DeathP01HL067849 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2001 to 2011
$15.0M
Strain Controlled LVAD Unloading and Post MI RemodelingR01HL081106 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P · 2006 to 2010
$3.4M
CELLULAR ORIGINS OF CARDIAC ARRHYTHMIASR01HL036974 · NHLBI · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI LEDERER, WILLIAM JONATHAN · 1987 to 2007
$1.5M
NHLBI NIH HHS P01 HL67849NHLBI NIH HHS R01 HL081106NHLBI NIH HHS R01 HL 36974
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntidotesArrhythmias, CardiacCalciumCalcium-Binding ProteinsCalcium SignalingFlecainideHumansMiceRatsAntidotescaisequestrin 2, ratCalciumCalcium-Binding ProteinsFlecainide

Identifiers

PMID19931542
OpenAlexW1998197670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.