ArticleNeuroImage2010
BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Functional brain imaging studies of youth depression: a systematic review.NeuroImage. Clinical · 2014Pooled it
- Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder.Brain imaging and behavior · 2011Pooled it
- Effects of the BDNF Val66Met polymorphism and met allele load on declarative memory related neural networks.PloS one · 2013Trial
- Relationship between BDNF rs6265 (VAL66MET) polymorphism and serum BDNF LEVELS in anxiety disorders.Molecular biology reports · 2026Article
- Oscillatory brain dynamics underlying affective face processing.Social cognitive and affective neuroscience · 2025Article
- Graph theory-driven structural and functional connectivity analyses revealing regulatory mechanisms of brain network in patients with classic trigeminal neuralgia.Brain imaging and behavior · 2025Article
- BDNF: New Views of an Old Player in Traumatic Brain Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls.BMC psychiatry · 2024Article
- Subfield-specific longitudinal changes of hippocampal volumes in patients with early-stage bipolar disorder.Bipolar disorders · 2023Article
- Amygdala's T1-weighted image radiomics outperforms volume for differentiation of anxiety disorder and its subtype.Frontiers in psychiatry · 2023Article
- Depression in Adolescence and Brain-Derived Neurotrophic Factor.Frontiers in molecular neuroscience · 2022Review
- Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats.Journal of neuroscience research · 2021Article
- Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype.Translational psychiatry · 2021Article
- Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021Review
- Age-related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields.Hippocampus · 2021Article
- A Novel Sulfonamide, 4-FS, Reduces Ethanol Drinking and Physical Withdrawal Associated With Ethanol Dependence.International journal of molecular sciences · 2020Article
- Brain-derived neurotrophic factor association with amygdala response in major depressive disorder.Journal of affective disorders · 2020Article
- The role of BDNF methylation and ValHuman brain mapping · 2020Article
- DNA Methylation within the Amygdala Early in Life Increases Susceptibility for Depression and Anxiety Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hippocampal-subregion functional alterations associated with antidepressant effects and cognitive impairments of electroconvulsive therapy.Psychological medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. Associations between BDNF gene variants and brain activity have not been explored in anxious and depressed adolescents. The current study investigated the association between BDNF genotype and amygdala-hippocampal responses to emotional stimuli in adolescents with anxiety disorders and/or major depressive disorder (MDD) and in healthy adolescents. Twenty-seven unmedicated patients with acutely-impairing current anxiety disorders and/or MDD and 31 healthy adolescents, matched on age, gender and IQ, rated their fear of fearful, angry, neutral and happy facial expressions during collection of fMRI data on the amygdala and hippocampus. Left and right amygdala and hippocampal responses were analyzed using repeated-measures analyses of variance models, with diagnosis (patients, healthy) and genotype (Met-carriers, Val/Val homozygotes) as between-group factors and facial expression (fearful, angry, neutral, happy) as a within-subject factor. Significant effects of diagnosis and diagnosis-by-genotype interactions (F's>4, p's<0.05) characterized activations in amygdala and anterior hippocampal regions. Greater activations in patients than healthy adolescents were found. Critically, these hyperactivations were modulated by BDNF genotype: Met-carriers showed greater neural responses of emotional faces than Val/Val homozygotes in patients only. These data are first to demonstrate the contribution of BDNF gene variants to the neural correlates of adolescent anxiety and depression. Early "gene-brain" linkages may lay the foundation for longer-term patterns of neural dysfunction in affective disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.