ArticleMicrobial pathogenesis2010
Patients with Chlamydia-associated arthritis have ocular (trachoma), not genital, serovars of C. trachomatis in synovial tissue.
Article in Microbial pathogenesis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 52 citations in OpenAlex.
- Microbes, helminths, and rheumatic diseases.Best practice & research. Clinical rheumatology · 2020Review
- Sexually acquired reactive arthritis.Clinical medicine (London, England) · 2016Article
- Causality of Chlamydiae in Arthritis and Spondyloarthritis: a Plea for Increased Translational Research.Current rheumatology reports · 2016Review
- Complete Genome Sequence of Chlamydia trachomatis Ocular Serovar C Strain TW-3.Genome announcements · 2014Article
- The role of intracellular organisms in the pathogenesis of inflammatory arthritis.International journal of inflammation · 2014Review
- The gastrointestinal microbiome and musculoskeletal diseases: a beneficial role for probiotics and prebiotics.Pathogens (Basel, Switzerland) · 2013Article
- Chlamydia trachomatis is present and metabolically active during the remitting phase in synovial tissues from patients with chronic Chlamydia-induced reactive arthritis.The American journal of the medical sciences · 2013Article
- Feast or famine: the host-pathogen battle over amino acids.Cellular microbiology · 2013Review
- The molecular basis for disease phenotype in chronic Chlamydia-induced arthritis.International journal of clinical rheumatology · 2012Article
- Chlamydia-induced ReA: immune imbalances and persistent pathogens.Nature reviews. Rheumatology · 2011Article
- Combination antibiotics for the treatment of Chlamydia-induced reactive arthritis: is a cure in sight?International journal of clinical rheumatology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Some individuals with a genital Chlamydia trachomatis infection develop inflammatory arthritis, but it is unknown whether particular chlamydial serovar(s) engender the disease more often than others. We defined serovar in synovial tissues from arthritis patients infected with this organism. DNA from synovial biopsies of 36 patients with PCR-confirmed synovial C. trachomatis was analyzed. Diagnoses included reactive arthritis, undifferentiated oligoarthritis, rheumatoid arthritis, and osteoarthritis. The chlamydial omp1 and trpA genes were amplified, cloned, and 10 or more clones from each sample were sequenced. The cytotoxin locus also was analyzed. omp1 sequences showed 2 patients having only C. trachomatis A serovar, 1 with only B, and 33 having only C, all ocular serovars. Analyses of trpA and the cytotoxin locus uniformly displayed standard ocular serovar characteristics for each patient. Identification of ocular chlamydial serovars in the synovia of arthritis patients is unexpected. These observations suggest that urogenital chlamydial infections, while consisting primarily of organisms of genital serovars, include some of ocular serovar(s). They further suggest that during such infections unknown selection pressures favor establishment of the latter in the synovium to the exclusion of genital serovar chlamydiae.
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Registered trials
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