ArticleInfectious agents and cancer2009
Epithelial maturation and molecular biology of oral HPV.
Article in Infectious agents and cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 83 citations in OpenAlex.
- HPV in oropharyngeal squamous papillomas: a missing link in head and neck viral pathogenesis.Virchows Archiv : an international journal of pathology · 2026Article
- Article
- Article
- Viral infection and antiviral immunity in the oral cavity.Nature reviews. Immunology · 2025Review
- Impact of HPV-16 Lineages Infection in Response to Radio-Chemotherapy in Cervical Cancer.Biomedicines · 2023Article
- Temperature-regulated type II grass carp reovirus establishes latent infection in Ctenopharyngodon idella brain.Virologica Sinica · 2023Article
- Molecular Patho-mechanisms of cervical cancer (MMP1).Annals of medicine and surgery (2012) · 2022Review
- Stakeholders' Understandings of Human Papillomavirus (HPV) Vaccination in Sub-Saharan Africa: A Rapid Qualitative Systematic Review.Vaccines · 2021Review
- Dysbiosis of Oral Microbiota During Oral Squamous Cell Carcinoma Development.Frontiers in oncology · 2021Article
- Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa.Advances in virology · 2020Article
- Article
- Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient.Oral oncology · 2017Article
- Human papillomavirus and gastrointestinal cancer in Iranian population: A systematic review and meta-analysis.Caspian journal of internal medicine · 2017Review
- Effectiveness of Toki's criteria and determination of variables for identification of HPV L1 protein in oral lesions.Medicina oral, patologia oral y cirugia bucal · 2014Article
- Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors.Scientific reports · 2014Article
- An update on oral human papillomavirus infection.Indian journal of sexually transmitted diseases and AIDS · 2013Review
- Biomarkers of HPV in head and neck squamous cell carcinoma.Cancer research · 2012Article
- Oral infection by the Human Papilloma Virus in women with cervical lesions at a prison in São Paulo, Brazil.Brazilian journal of otorhinolaryngology · 2012Article
- Oral Leukoplakia as It Relates to HPV Infection: A Review.International journal of dentistry · 2012Article
- New Concepts for Translational Head and Neck Oncology: Lessons from HPV-Related Oropharyngeal Squamous Cell Carcinomas.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human papillomavirus (HPV) is widespread and can cause latent infection in basal cells, with low HPV DNA copy-number insufficient for transmission of infection; can cause subclinical infection that is active but without clinical signs; or can cause clinical infection leading to benign, potentially malignant or malignant lesions. The HPV cycle is influenced by the stage of maturation of the infected keratinocytes, and the production of virions is restricted to the post-mitotic suprabasal epithelial cells where all the virus genes are expressed.Low-risk HPV genotypes are associated with the development of benign oral lesions, whereas high-risk HPV genotypes are implicated in the development of malignant epithelial neoplasms. The rôle of high-risk HPV as a causative agent in epithelial malignancy is different at different anatomical sites: it is almost invariably implicated in squamous cell carcinoma of the uterine cervix, fairly frequently implicated in squamous cell carcinoma of the oropharynx, and it is seldom implicated in squamous cell carcinoma of the mouth.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.