ArticleBiology direct2009
Evolution by leaps: gene duplication in bacteria.
Article in Biology direct, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 83 citations in OpenAlex.
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- Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness ofbioRxiv : the preprint server for biology · 2024Article
- Cofactor maturase NifEN: A prototype ancient nitrogenase?Science advances · 2024Article
- Identification of the mechanism for dehalorespiration of monofluoroacetate in the phylum Synergistota.Animal bioscience · 2024Article
- Structures of Get3d reveal a distinct architecture associated with the emergence of photosynthesis.The Journal of biological chemistry · 2023Article
- Differential Expression of Two Copies of theMicrobiology spectrum · 2022Article
- Molecular characterization of a novel strain ofFrontiers in plant science · 2022Article
- Heterozygous, Polyploid, Giant Bacterium, Achromatium, Possesses an Identical Functional Inventory Worldwide across Drastically Different Ecosystems.Molecular biology and evolution · 2021Article
- The Role of Gene Duplication in the Divergence of Enzyme Function: A Comparative Approach.Frontiers in genetics · 2021Article
- A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries.PLoS computational biology · 2020Article
- Syntax and compositionality in animal communication.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Gene Duplications in the Genomes of Staphylococci and Enterococci.Frontiers in molecular biosciences · 2020Article
- Gene duplications in the E. coli genome: common themes among pathotypes.BMC genomics · 2019Article
- The genetic basis for adaptation of model-designed syntrophic co-cultures.PLoS computational biology · 2019Article
- The DEAD-Box RNA Helicases ofFrontiers in microbiology · 2018Article
- Comparative Transcriptome Analysis ofFrontiers in microbiology · 2018Article
- Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.BMC genomics · 2017Article
- Crosstalk and the Dynamical Modularity of Feed-Forward Loops in Transcriptional Regulatory Networks.Biophysical journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSequence related families of genes and proteins are common in bacterial genomes. In Escherichia coli they constitute over half of the genome. The presence of families and superfamilies of proteins suggest a history of gene duplication and divergence during evolution. Genome encoded protein families, their size and functional composition, reflect metabolic potentials of the organisms they are found in. Comparing protein families of different organisms give insight into functional differences and similarities.
resultsEquivalent enzyme families with metabolic functions were selected from the genomes of four experimentally characterized bacteria belonging to separate genera. Both similarities and differences were detected in the protein family memberships, with more similarities being detected among the more closely related organisms. Protein family memberships reflected known metabolic characteristics of the organisms. Differences in divergence of functionally characterized enzyme family members accounted for characteristics of taxa known to differ in those biochemical properties and capabilities. While some members of the gene families will have been acquired by lateral exchange and other former family members will have been lost over time, duplication and divergence of genes and functions appear to have been a significant contributor to the functional diversity of today's microbes.
conclusionsProtein families seem likely to have arisen during evolution by gene duplication and divergence where the gene copies that have been retained are the variants that have led to distinct bacterial physiologies and taxa. Thus divergence of the duplicate enzymes has been a major process in the generation of different kinds of bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.