ArticleCritical care (London, England)2009
Effect of fluid resuscitation on mortality and organ function in experimental sepsis models.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Accumulation of hydroxyethyl starch in human and animal tissues: a systematic review.Intensive care medicine · 2014Pooled it
- The effects of fluid balance and colloid administration on outcomes in patients with aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis.Neurocritical care · 2013Trial
- Urolithin A preserves renal perfusion and function and attenuates inflammasome-associated signaling in a translational porcine model of sepsis-induced acute kidney injury.Research square · 2026Article
- Article
- How can assessing hemodynamics help to assess volume status?Intensive care medicine · 2022Review
- Corrected flow time and respirophasic variation in blood flow peak velocity of radial artery predict fluid responsiveness in gynecological surgical patients with mechanical ventilation.BMC anesthesiology · 2022Article
- Overexpression of interleukin-10 in engineered macrophages protects endothelial cells against LPS-induced injury in vitro.FEBS open bio · 2022Article
- Comparison of the Efficacy of Different Arterial Waveform-derived Variables (Pulse Pressure Variation, Stroke Volume Variation, Systolic Pressure Variation) for Fluid Responsiveness in Hemodynamically Unstable Mechanically Ventilated Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- The inspiration hold maneuver is a reliable method to assess mean systemic filling pressure but its clinical value remains unclear.Annals of translational medicine · 2020Article
- Regional venous-arterial COIntensive care medicine experimental · 2020Article
- Rethinking animal models of sepsis - working towards improved clinical translation whilst integrating the 3Rs.Clinical science (London, England : 1979) · 2020Review
- Minimizing catecholamines and optimizing perfusion.Critical care (London, England) · 2019Review
- Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice.Journal of the American Heart Association · 2019Article
- Current aspects in sepsis approach. Turning things around.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Review
- Point-of-Care Ultrasound Identifies Decompensated Heart Failure in a Young Male with Methamphetamine-Associated Cardiomyopathy Presenting in Severe Sepsis to the Emergency Department.Case reports in emergency medicine · 2018Article
- Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis.Critical care (London, England) · 2017Article
- Review
- Volume Overload: Prevalence, Risk Factors, and Functional Outcome in Survivors of Septic Shock.Annals of the American Thoracic Society · 2015Article
- Reliability of Continuous Non-Invasive Assessment of Hemoglobin and Fluid Responsiveness: Impact of Obesity and Abdominal Insufflation Pressures.Obesity surgery · 2015Observational
- Current concept of abdominal sepsis: WSES position paper.World journal of emergency surgery : WJES · 2014Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeveral recent studies have shown that a positive fluid balance in critical illness is associated with worse outcome. We tested the effects of moderate vs. high-volume resuscitation strategies on mortality, systemic and regional blood flows, mitochondrial respiration, and organ function in two experimental sepsis models.
methods48 pigs were randomized to continuous endotoxin infusion, fecal peritonitis, and a control group (n = 16 each), and each group further to two different basal rates of volume supply for 24 hours [moderate-volume (10 ml/kg/h, Ringer's lactate, n = 8); high-volume (15 + 5 ml/kg/h, Ringer's lactate and hydroxyethyl starch (HES), n = 8)], both supplemented by additional volume boli, as guided by urinary output, filling pressures, and responses in stroke volume. Systemic and regional hemodynamics were measured and tissue specimens taken for mitochondrial function assessment and histological analysis.
resultsMortality in high-volume groups was 87% (peritonitis), 75% (endotoxemia), and 13% (controls). In moderate-volume groups mortality was 50% (peritonitis), 13% (endotoxemia) and 0% (controls). Both septic groups became hyperdynamic. While neither sepsis nor volume resuscitation strategy was associated with altered hepatic or muscle mitochondrial complex I- and II-dependent respiration, non-survivors had lower hepatic complex II-dependent respiratory control ratios (2.6 +/- 0.7, vs. 3.3 +/- 0.9 in survivors; P = 0.01). Histology revealed moderate damage in all organs, colloid plaques in lung tissue of high-volume groups, and severe kidney damage in endotoxin high-volume animals.
conclusionsHigh-volume resuscitation including HES in experimental peritonitis and endotoxemia increased mortality despite better initial hemodynamic stability. This suggests that the strategy of early fluid management influences outcome in sepsis. The high mortality was not associated with reduced mitochondrial complex I- or II-dependent muscle and hepatic respiration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.