ArticleBMC gastroenterology2009
Vitamin E (alpha-tocopherol) supplementation in diabetic rats: effects on the proximal colon.
Article in BMC gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Neuroprotective Effects ofJournal of clinical practice and research · 2024Article
- Article
- Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3 inflammasome in alloxan-induced diabetic mice.Nutrition research and practice · 2019Article
- Antioxidant Effects of the Quercetin in the Jejunal Myenteric Innervation of Diabetic Rats.Frontiers in medicine · 2017Article
- The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy.Journal of diabetes research · 2017Review
- Profile of glycated-hemoglobin, antioxidant vitamin and cytokine levels in pulmonary tuberculosis patients: A cross sectional study at Pulmonary Diseases Center Semarang City, Indonesia.Biomedical journal · 2016Article
- Antioxidant strategies in the management of diabetic neuropathy.BioMed research international · 2015Review
- Aqueous Extract of Agaricus blazei Murrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Neuroprotective effect of quercetin on the duodenum enteric nervous system of streptozotocin-induced diabetic rats.Digestive diseases and sciences · 2012Article
- L-glutamine supplementation prevents myenteric neuron loss and has gliatrophic effects in the ileum of diabetic rats.Digestive diseases and sciences · 2011Article
- Nutritional supplements and their effect on glucose control.Current diabetes reports · 2011Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuropathy is one of the complications caused by diabetes mellitus which is directly related to the gastrointestinal manifestations of the disease. Antioxidant substances, such as vitamin E, may play an important role in the reduction of the neurological damage caused by diabetes mellitus. The aim of the present study was to determine whether vitamin E (alpha-tocopherol) at different concentrations induces any effects on the morphology of the intestinal wall and intrinsic innervation in the proximal colon of diabetic rats.
methodsThirty rats (90-day-old) were assigned to the following groups: N (normoglycemic), NE1 (normoglycemic supplemented with vitamin E 0.1%), NE2 (normoglycemic supplemented with vitamin E 2%), D (diabetic), DE1 (diabetic supplemented with vitamin E 0.1%), and DE2 (diabetic supplemented with vitamin E 2%). Animals received vitamin E supplementation for 120 days and were sacrificed when they were 210 days old. The proximal colon of each animal was subjected to histology to study the intestinal wall and goblet cells and processed for whole-mount preparations to morphoquantitatively determine the total myenteric population.
resultsSupplementation with vitamin E significantly reduced glycemia and glycated hemoglobin values and preserved the number of myenteric neurons in group DE2, without affecting intestinal area or thickness of the intestinal wall or muscular tunic.
conclusionVitamin E (2%) influenced the glycemic parameters and had a neuroprotective effect on the total myenteric population, but the morphometric characteristics of the intestinal wall were unaffected.
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