ReviewExpert review of proteomics2009
Role for protein-protein interaction databases in human genetics.
Review in Expert review of proteomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Identification of high-risk non-synonymous SNPs (nsSNPs) in DNAH1 and DNAH17 genes associated with male infertility: a bioinformatics analysis.Journal of applied genetics · 2025Article
- A determination of pan-pathogen antimicrobials?Medicine in drug discovery · 2022Review
- Overview of methods for characterization and visualization of a protein-protein interaction network in a multi-omics integration context.Frontiers in molecular biosciences · 2022Review
- The design and development of covalent protein-protein interaction inhibitors for cancer treatment.Journal of hematology & oncology · 2020Review
- Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.American journal of human genetics · 2019Article
- An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration.NPJ systems biology and applications · 2019Article
- Benchmarking selected computational gene network growing tools in context of virus-host interactions.Scientific reports · 2017Article
- Improving analytical methods for protein-protein interaction through implementation of chemically inducible dimerization.Scientific reports · 2016Article
- Pathway Analysis Incorporating Protein-Protein Interaction Networks Identified Candidate Pathways for the Seven Common Diseases.PloS one · 2016Article
- Article
- Integrated neurobiology of bipolar disorder.Frontiers in psychiatry · 2014Review
- Bioinformatic prediction of WSSV-host protein-protein interaction.BioMed research international · 2014Article
- Integration of biological networks and pathways with genetic association studies.Human genetics · 2012Review
- High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions.PloS one · 2012Article
- An organogenesis network-based comparative transcriptome analysis for understanding early human development in vivo and in vitro.BMC systems biology · 2011Article
- The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored.Nucleic acids research · 2011Article
- Intercellular interactomics of human brain endothelial cells and th17 lymphocytes: a novel strategy for identifying therapeutic targets of CNS inflammation.Cardiovascular psychiatry and neurology · 2011Article
- Identification of epistatic effects using a protein-protein interaction database.Human molecular genetics · 2010Article
- Bioinformatics challenges for genome-wide association studies.Bioinformatics (Oxford, England) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly available to the scientific community. As our knowledge of protein-protein interactions increases, it is important to give thought to the different ways that these resources can impact biomedical research. In this article, we highlight the importance of protein-protein interactions in human genetics and genetic epidemiology. Since protein-protein interactions demonstrate one of the strongest functional relationships between genes, combining genomic data with available proteomic data may provide us with a more in-depth understanding of common human diseases. In this review, we will discuss some of the fundamentals of protein interactions, the databases that are publicly available and how information from these databases can be used to facilitate genome-wide genetic studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.