ArticleExpert review of proteomics2009
Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations.
Article in Expert review of proteomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggeredFrontiers in molecular neuroscience · 2026Article
- Integrating the analysis of human biopsies using post-translational modifications proteomics.Protein science : a publication of the Protein Society · 2024Review
- Comparative Proteomic and Phospho-proteomic Analysis of Mouse Placentas Generated via In Vivo and In Vitro Fertilization.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Phosphoprotein Profile of Rice (Plants (Basel, Switzerland) · 2022Article
- Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis.Frontiers in genetics · 2022Article
- Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA).BMC cancer · 2021Article
- Post-Translational Modifications of Deubiquitinating Enzymes: Expanding the Ubiquitin Code.Frontiers in pharmacology · 2021Review
- Fractionation of Enriched Phosphopeptides Using pH/Acetonitrile-Gradient-Reversed-Phase Microcolumn Separation in Combination with LC-MS/MS Analysis.International journal of molecular sciences · 2020Article
- Phosphokinase antibody arrays on dendron-coated surface.PloS one · 2014Article
- Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.BMC evolutionary biology · 2013Article
- Role of LRF/Pokemon in lineage fate decisions.Blood · 2013Review
- Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.BMC cell biology · 2013Article
- Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Chemical research in toxicology · 2012Review
- Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion.Molecular and cellular endocrinology · 2012Article
- Identification and validation of inhibitor-responsive kinase substrates using a new paradigm to measure kinase-specific protein phosphorylation index.Journal of proteome research · 2012Article
- Article
- A survey of computational methods and error rate estimation procedures for peptide and protein identification in shotgun proteomics.Journal of proteomics · 2010Review
- Functional proteomics to dissect tyrosine kinase signalling pathways in cancer.Nature reviews. Cancer · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Phosphorylation of proteins is a predominant, reversible post-translational modification. It is central to a wide variety of physiological responses and signaling mechanisms. Recent advances have allowed the global scope of phosphorylation to be addressed by mass spectrometry using phosphoproteomic approaches. In this perspective, we discuss four aspects of phosphoproteomics: the insights and implications from recently published phosphoproteomic studies and the applications and limitations of current phosphoproteomic strategies. Since approximately 50,000 known phosphorylation sites do not yet have any ascribed function, we present our perspectives on a major function of protein phosphorylation that may be of predictive value in hypothesis-based investigations. Finally, we discuss strategies to measure the stoichiometry of phosphorylation in a proteome-wide manner that is not provided by current phosphoproteomic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.