ArticleJournal of the American Chemical Society2009
Unnatural amino acid substitution as a probe of the allosteric coupling pathway in a mycobacterial Cu(I) sensor.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking.Chemical reviews · 2024Review
- Characterization of the Zinc Uptake Repressor (Zur) fromBiochemistry · 2024Article
- Unique underlying principles shaping copper homeostasis networks.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Review
- Functional asymmetry and chemical reactivity of CsoR family persulfide sensors.Nucleic acids research · 2021Article
- Molecular Insights into the Copper-Sensitive Operon Repressor in Acidithiobacillus caldus.Applied and environmental microbiology · 2021Article
- Nickel Metalloregulators and Chaperones.Inorganics · 2019Article
- The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis inThe Journal of biological chemistry · 2019Article
- TheThe Journal of biological chemistry · 2019Article
- Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY fromChemical science · 2018Article
- Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR.Inorganic chemistry · 2017Article
- The mechanism of a formaldehyde-sensing transcriptional regulator.Scientific reports · 2016Article
- Resolution of Stepwise Cooperativities of Copper Binding by the Homotetrameric Copper-Sensitive Operon Repressor (CsoR): Impact on Structure and Stability.Angewandte Chemie (International ed. in English) · 2015Article
- Generating a Metal-responsive Transcriptional Regulator to Test What Confers Metal Sensing in Cells.The Journal of biological chemistry · 2015Article
- The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus.Molecular microbiology · 2014Article
- Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR).The Journal of biological chemistry · 2014Article
- Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS.Molecular microbiology · 2014Article
- Insights into Protein Allostery in the CsoR/RcnR Family of Transcriptional Repressors.Chemistry letters · 2014Article
- Physical characterization of the manganese-sensing pneumococcal surface antigen repressor from Streptococcus pneumoniae.Biochemistry · 2013Article
- Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.Journal of molecular biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The Cu(I) sensor Mycobacterium tuberculosis CsoR is a founding member of a new metalloregulatory protein family. Here we show that two "atom" substitutions of the Nepsilon2 face of a Cu(I) coordinating histidine-61 allosterically uncouple Cu(I) and DNA binding, with no effect on Cu(I) binding affinity and coordination structure. A model analogous to the allosteric switch mechanism in Staphylococcus aureus CzrA, a zinc sensor protein with a completely different fold, is proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.