ArticleACS nano2009
Multilayered polyelectrolyte films: from active molecular delivery to vaccine therapy.
Article in ACS nano, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Abstract
A paper in this issue discusses the use of multilayered polyelectrolyte films incorporating a hydrolytically degradable polymer for transcutaneous drug or vaccine delivery. Dried films could be deconstructed rapidly, and a model protein antigen (ovalbumin) and/or immunostimulatory molecules could be released with different kinetics. Both molecules could also be delivered to antigen-presenting cells in the skin (Langerhans cells). The described approach provides a new route for the storage of vaccines. Successful antigen processing and presentation to lymphocytes remain ongoing challenges before the concept can be used in the next generation of vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.