SynthesisSleep2009
Lack of association of the APOE epsilon 4 allele with the risk of obstructive sleep apnea: meta-analysis and meta-regression.
Synthesis in Sleep, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Apolipoprotein E ɛ2/ɛ3/ɛ4 variant in association with obstructive sleep apnoea and lipid profile: A meta-analysis.The Journal of international medical research · 2016Pooled it
- Obstructive Sleep Apnea Susceptibility Genes in Chinese Population: A Field Synopsis and Meta-Analysis of Genetic Association Studies.PloS one · 2015Pooled it
- A review of genetic association studies of obstructive sleep apnea: field synopsis and meta-analysis.Sleep · 2011Pooled it
- Impact of Alzheimer's disease on sleep in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ4 allele carriers.Sleep · 2024Article
- Sex andJournal of neurophysiology · 2024Article
- Respiratory Dysfunction in Alzheimer's Disease-Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions.International journal of molecular sciences · 2024Review
- Association Between Slow-Wave Sleep Loss and Incident Dementia.JAMA neurology · 2023Article
- APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia.Alzheimer's research & therapy · 2022Article
- Obstructive Sleep Apnea and Cognitive Decline: A Review of Potential Vulnerability and Protective Factors.Brain sciences · 2021Review
- Obstructive Sleep Apnea and Its Treatment in Aging: Effects on Alzheimer's disease Biomarkers, Cognition, Brain Structure and Neurophysiology.Neurobiology of disease · 2020Review
- Prevalence of obstructive sleep apnea in Alzheimer's disease patients.Journal of neurology · 2020Observational
- Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.International journal of molecular epidemiology and genetics · 2019Article
- The genetics of obstructive sleep apnoea.Respirology (Carlton, Vic.) · 2018Review
- Results of Polysomnographies and Treatment Strategies in Elderly Patients with Symptoms of Obstructive Sleep Apnea Syndrome.Turkish thoracic journal · 2017Article
- Sleep disordered breathing at the extremes of age: the elderly.Breathe (Sheffield, England) · 2016Review
- Examining the association between Apolipoprotein E (APOE) and self-reported sleep disturbances in non-demented older adults.Neuroscience letters · 2015Article
- No association between the ApoE ε2 and ε4 alleles and the risk of obstructive sleep apnea: A systematic review and meta-analysis.Biomedical reports · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesReports on the association of polymorphisms in the gene encoding apolipoprotein E (APOE)--a vital macromolecule in cholesterol metabolism--with obstructive sleep apnea (OSA) have provided conflicting results. Our objective was to meta-analytically synthesize the existing evidence for the association of the APOE epsilon4 allele with the risk of OSA.
designRandom effects meta-analysis and meta-regression.
settingGenetic epidemiological studies reporting the association of APOE epsilon4 allele with OSA susceptibility. PATIENTS OR
participantsSynthesis of APOE epsilon4 allele data from 6,508 subjects including 1,901 cases of OSA and 4,607 controls.
interventionsNone. MEASUREMENTS AND
resultsEight studies were included in the random effects meta-analysis; the summary effect size measured as odds ratio (OR) for association of the APOE epsilon4 allele with the risk of OSA was found to be 1.13 (95% confidence interval 0.86-1.47). There was a statistically significant heterogeneity (I2 = 72%, P = 0.001) across study results that was not explained by the mean age, proportion of males, or the proportion possessing the APOE epsilon4 allele or when grouped based on the geographic location of the study.
conclusionsThe hypothesis that the APOE epsilon4 allele may be causally associated with OSA cannot be supported on the basis of published literature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.