ArticleEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2010
The relation of leptin and adiponectin with breast density among premenopausal women.
Article in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Circulating adiponectin and breast cancer risk: a systematic review and meta-analysis.International journal of epidemiology · 2014Pooled it
- Prognostic effect of circulating adiponectin in a randomized 2 x 2 trial of low-dose tamoxifen and fenretinide in premenopausal women at risk for breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- Lipidome of mammographic breast density in premenopausal women.Breast cancer research : BCR · 2023Article
- Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Type 2 diabetes and mammographic breast density among underserved women.Cancer causes & control : CCC · 2015Article
- Plasma leptin levels, LEPR Q223R polymorphism and mammographic breast density: a cross-sectional study.The International journal of biological markers · 2013Article
- The tetrad BMI, leptin, leptin/adiponectin (L/A) ratio and CA 15-3 are reliable biomarkers of breast cancer.Journal of clinical laboratory analysis · 2013Article
- Plasma matrix metalloproteinases and postmenopausal breast cancer risk: a nested case-control study in the Multiethnic Cohort study.Breast cancer research and treatment · 2012Article
- Adiponectin and breast cancer.Medical oncology (Northwood, London, England) · 2011Review
- Dense breast tissue in postmenopausal women is associated with a pro-inflammatory microenvironmentOncoimmunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The adipocytokine leptin may increase breast cancer risk, while adiponectin may be protective. We examined the association of the two circulating markers with mammographic density, a strong predictor of breast cancer risk. For 183 premenopausal participants of a nutritional trial, mammograms performed at baseline, year 1 and year 2 were assessed for density using a computer-assisted method. Serum samples obtained at the same time were analyzed for leptin and adiponectin by enzyme-linked immunosorbent assay. We applied mixed models to incorporate the repeated measurements while adjusting for confounders including body mass index (BMI). At baseline, the mean age of the participants was 42.6+/-2.9 years; 40% were of Asian ancestry. Leptin was lower and adiponectin higher in normal weight than overweight women. Neither marker was related to absolute breast density. The significant inverse association of leptin with percent density disappeared when BMI was added to the model. After stratification by weight, percent density decreased with higher leptin levels in normal weight women, whereas it increased among overweight participants. After adjustment for BMI, the positive association between percent density and adiponectin was greatly reduced and no longer significant. These results do not support a strong association of leptin or adiponectin with breast cancer risk as assessed by mammographic density. In contrast, the findings suggest the possibility that the inverse association of BMI with breast cancer risk in premenopausal women is mediated by adipocytokines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.